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Behçet Syndrome and Microbes

  • Farida FortuneEmail author
  • Gulen Hatemi
Chapter

Abstract

Behçet syndrome (BS) is generally thought to have a complex genetic background where both innate and adaptive immune systems are activated through environmental factors including infections and autoantigens. There are clues to support the role of several different microorganisms including viruses and bacteria, which may be using a common pathway to trigger or activate the inflammation in BS through molecular mimicry. Due to the significant homology between microbial and human heat shock proteins (HSPs), it is suggested that HSPs could be such common triggers. Recent studies on microbiome of patients with BS show distinct features that may help us understand its pathogenesis.

Keywords

Behçet syndrome Infections Microorganisms Virus Bacteria Microbiota Heat shock proteins Molecular mimicry 

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Authors and Affiliations

  1. 1.Queen Mary University of London- Barts and The London School of Medicine and Dentistry, London Behçet’s CentreLondonUK
  2. 2.Department of Internal Medicine, Division of RheumatologyIstanbul University-Cerrahpasa, School of MedicineIstanbulTurkey

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