Siliconomas are pseudotumors formed by infiltration of tissues by silicone and the consequent granulomatous reaction. They may be due to direct infiltration of silicones or from rupture of a breast prosthesis; in both instances, the histological characteristics of the granulomatous reaction are similar.
Histologically, silicones are observed, partly, as deposits of an extracellular exogenous material that does not stain in Hematoxylin Eosin-histologic sections. They have a variable diameter, with well-defined and refringent edges, sometimes with an acidophilic hyaline membrane. This is surrounded by an histiocytic granulomatous reaction, the histiocytes have microvacuoles in their cytoplasm, which is the other way in which silicones are observed in tissues. Microvacuoles are also refringent, which differentiates them from the lipophagic histiocytes observed in adipose tissue necrosis. The granulomatous reaction of siliconomas frequently includes multinucleated giant cells, also with silicone microvacuoles; in some cases, asteroid bodies, similar to those seen in sarcoidosis, are observed within the vacuoles.
We now present a case of a siliconoma, formed after the direct injection of liquid silicone, within which a carcinoma developed. We believe that these images, of a carcinoma infiltrating a siliconoma, are unique, since we have been unable to find any others similar to this in the medical literature.
Filtration of silicone Histology Anatomic pathology Immune response Infiltrating carcinoma Reaction of autoimmunity
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