Urine Cytology

  • Nikolina Dioufa
  • Gina Prochilo
  • Suad TaraifEmail author
Part of the Practical Anatomic Pathology book series (PAP)


Urine cytology remains the single most practical tool to detect and follow up bladder carcinoma, especially for high-grade urothelial carcinoma. The introduction and continued acceptance of the Paris System for Reporting Urinary Cytology will certainly improve the sensitivity and specificity of urine cytology for high-grade urothelial carcinoma diagnosis. In this chapter, we start with questions about urine cytology commonly encountered in cytology practice: from specimen preparation to recognizing the cellular and noncellular components of urine specimens in voided, instrumented, and loop urine samples. We then move on to describe benign reactive changes of urothelial cells, low-grade urothelial neoplasms, and high-grade urothelial carcinomas; common urothelial carcinoma mimics like “decoy” cells and metastatic urinary tract carcinomas are also discussed. The case presentation at the end of the chapter will further emphasize the key concepts and diagnostic points.


Urine cytology Paris System for Reporting Urinary Cytology Urothelial carcinoma Polyoma virus Specimen preparation 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineTemple University HospitalPhiladelphiaUSA
  2. 2.Department of PathologyRobert Wood Johnson University HospitalNew BrunswickUSA

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