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Soft Tissue and Bone

  • Xiaohua QianEmail author
  • Yaxia Zhang
Chapter
Part of the Practical Anatomic Pathology book series (PAP)

Abstract

Preoperative diagnosis of soft tissue and bone tumors using needle biopsy techniques, namely fine needle aspiration (FNA) and core needle biopsy (CNB), has gained wider acceptance in recent years. This is achieved in concert with the maturation of various image-guided needle biopsy techniques, development of molecular genetic diagnostics, and expansion of immunohistochemical biomarkers. FNA, however, as a first-line approach to evaluate soft tissue and bone tumors, remains one of the most challenging and controversial areas in cytopathology. Compared with the CNB, FNA is more suitable for smaller lesions, recurrent and/or metastatic tumors, and lesions with a broad differential diagnosis including carcinomas and lymphomas. Enhanced by rapid on-site evaluation (ROSE), and immediate tissue triage for flow cytometry and/or cytogenetic/molecular studies, FNA offers a valuable and fast diagnostic modality for lesions suspicious for high grade malignancy. This chapter focuses on the practical approaches to this extremely diverse set of benign and malignant neoplasms, emphasizing on pattern recognition, effective triage of biopsy material, and judicious use of ancillary studies. General discussion of the clinical and cytomorphologic features of each entity is beyond the scope of this diagnostic approach–orientated chapter, and the readers are directed to other relevant excellent textbooks.

Keywords

Soft tissue Bone Sarcoma FNA Molecular Immunohistochemistry Fluorescence in situ hybridization 

References

  1. 1.
    Martin HE, Ellis EB. Biopsy by needle puncture and aspiration. Ann Surg. 1930;92(2):169–81.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Coley BL, Sharp GS, Ellis EB. Diagnosis of bone tumors by aspiration. Am J Surg. 1931;13(2):215–24.CrossRefGoogle Scholar
  3. 3.
    Qian X. Soft tissue. In: Cibas ES, editor. Cytology: diagnostic principles and clinical correlates. 4th ed. Philadelphia: Elsevier; 2014. p. 471–518.Google Scholar
  4. 4.
    Domanski HA, Qian X, Stanley DE. Chapter 16: Bone. In: Domanski HA, editor. Atlas of fine needle aspiration cytology. 2nd ed. London: Springer; 2019.CrossRefGoogle Scholar
  5. 5.
    Kilpatrick S. Diagnostic musculoskeletal surgical pathology: Saunders; 2003.Google Scholar
  6. 6.
    Jo VY, Qian X. Molecular diagnostics in bone and soft tissue tumors. In: Roy-Chowdhuri S, Vanderlaan PA, Stewart JM, da Cunha Santos G, editors. Molecular diagnostics in cytopathology: a practical handbook for the practicing pathologist. 1st ed. Cham, Switzerland: Springer; 2019.Google Scholar
  7. 7.
    Kubik MJ, Mohammadi A, Rosa M. Diagnostic benefits and cost-effectiveness of on-site imprint cytology adequacy evaluation of core needle biopsies of bone lesions. Diagn Cytopathol. 2014;42(6):506–13.CrossRefPubMedGoogle Scholar
  8. 8.
    Khalbuss WE, Teot LA, Monaco SE. Diagnostic accuracy and limitations of fine-needle aspiration cytology of bone and soft tissue lesions: a review of 1114 cases with cytological-histological correlation. Cancer Cytopathol. 2010;118(1):24–32.CrossRefPubMedGoogle Scholar
  9. 9.
    Fletcher CDM, Bridge J, Hogendoorn P, Mertens F, editors. World Health Organization classification of tumours. Pathology and genetics of tumours of soft tissue and bone. 4th ed. Geneva: IARC Press; 2013.Google Scholar
  10. 10.
    Murali R, Zarka MA, Ocal IT, Tazelaar HD. Cytologic features of epithelioid hemangioendothelioma. Am J Clin Pathol. 2011;136(5):739–46.CrossRefPubMedGoogle Scholar
  11. 11.
    Baez JC, Landry JM, Saltzman JR, Qian X, Zinner MJ, Mortele KJ. Pancreatic PEComa (sugar tumor): MDCT and EUS features. JOP. 2009;10(6):679–82.PubMedGoogle Scholar
  12. 12.
    Adams SC, Potter BK, Pitcher DJ, Temple HT. Office-based core needle biopsy of bone and soft tissue malignancies: an accurate alternative to open biopsy with infrequent complications. Clin Orthop Relat Res. 2010;468(10):2774–80.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Kilpatrick SE, Cappellari JO, Bos GD, Gold SH, Ward WG. Is fine-needle aspiration biopsy a practical alternative to open biopsy for the primary diagnosis of sarcoma? Experience with 140 patients. Am J Clin Pathol. 2001;115(1):59–68.CrossRefPubMedGoogle Scholar
  14. 14.
    Barrientos-Ruiz I, Ortiz-Cruz EJ, Serrano-Montilla J, Bernabeu-Taboada D, Pozo-Kreilinger JJ. Are biopsy tracts a concern for seeding and local recurrence in sarcomas? Clin Orthop Relat Res. 2017;475(2):511–8.CrossRefPubMedGoogle Scholar
  15. 15.
    Van Houdt WJ, Schrijver AM, Cohen-Hallaleh RB, et al. Needle tract seeding following core biopsies in retroperitoneal sarcoma. Eur J Surg Oncol. 2017;43(9):1740–5.CrossRefPubMedGoogle Scholar
  16. 16.
    Domanski HA. Sampling procedure, fine needle aspiration and core needle biopsy. In: Klijanienko J, Lagace R, editors. Soft tissue tumors. Hoboken: Wiley-Blackwell; 2011.Google Scholar
  17. 17.
    Dal Cin P, Qian X, Cibas ES. The marriage of cytology and cytogenetics. Cancer Cytopathol. 2013;121(6):279–90.CrossRefPubMedGoogle Scholar
  18. 18.
    Chebib I, Jo VY. Application of ancillary studies in soft tissue cytology using a pattern-based approach. Cancer Cytopathol. 2018;126(Suppl 8):691–710.CrossRefPubMedGoogle Scholar
  19. 19.
    Dodd LG. Update on liposarcoma: a review for cytopathologists. Diagn Cytopathol. 2012;40(12):1122–31.CrossRefPubMedGoogle Scholar
  20. 20.
    Al Hmada Y, Schaefer IM, Fletcher CDM. Hibernoma mimicking atypical Lipomatous tumor: 64 cases of a morphologically distinct subset. Am J Surg Pathol. 2018;42(7):951–7.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Lemos MM, Kindblom LG, Meis-Kindblom JM, et al. Fine-needle aspiration characteristics of hibernoma. Cancer. 2001;93(3):206–10.CrossRefPubMedGoogle Scholar
  22. 22.
    Domanski HA, Carlen B, Jonsson K, Mertens F, Akerman M. Distinct cytologic features of spindle cell lipoma. A cytologic-histologic study with clinical, radiologic, electron microscopic, and cytogenetic correlations. Cancer. 2001;93(6):381–9.CrossRefPubMedGoogle Scholar
  23. 23.
    Ferreira J, Esteves G, Fonseca R, Martins C, Andre S, Lemos MM. Fine-needle aspiration of lipoblastoma: cytological, molecular, and clinical features. Cancer Cytopathol. 2017;125(12):934–9.CrossRefPubMedGoogle Scholar
  24. 24.
    Gisselsson D, Domanski HA, Hoglund M, et al. Unique cytological features and chromosome aberrations in chondroid lipoma: a case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics. Am J Surg Pathol. 1999;23(10):1300–4.CrossRefPubMedGoogle Scholar
  25. 25.
    Dey P. Fine needle aspiration cytology of well-differentiated liposarcoma. A report of two cases. Acta Cytol. 2000;44(3):459–62.CrossRefPubMedGoogle Scholar
  26. 26.
    Klijanienko J, Caillaud JM, Lagace R. Fine-needle aspiration in liposarcoma: cytohistologic correlative study including well-differentiated, myxoid, and pleomorphic variants. Diagn Cytopathol. 2004;30(5):307–12.CrossRefPubMedGoogle Scholar
  27. 27.
    Dodd LG, Sara Jiang X, Rao K, Bui MM. Pleomorphic liposarcoma: a cytologic study of five cases. Diagn Cytopathol. 2015;43(2):138–43.CrossRefPubMedGoogle Scholar
  28. 28.
    Marino-Enriquez A, Hornick JL, Dal Cin P, Cibas ES, Qian X. Dedifferentiated liposarcoma and pleomorphic liposarcoma: a comparative study of cytomorphology and MDM2/CDK4 expression on fine-needle aspiration. Cancer Cytopathol. 2014;122(2):128–37.CrossRefPubMedGoogle Scholar
  29. 29.
    Zhou H, Guo M, Gong Y. Challenge of FNA diagnosis of angiomyolipoma: a study of 33 cases. Cancer Cytopathol. 2017;125(4):257–66.CrossRefPubMedGoogle Scholar
  30. 30.
    Collins K, Buckley T, Anderson K, Karasik M, Ligato S. Perivascular Epithelioid Cell Tumor (PEComa) of pancreas diagnosed preoperatively by endoscopic ultrasound-guided fine-needle aspiration: a case report and review of literature. Diagn Cytopathol. 2017;45(1):59–65.CrossRefPubMedGoogle Scholar
  31. 31.
    Skorpil M, Tani E, Blomqvist L. Presacral myelolipoma in a patient with rectal cancer: diagnosis by magnetic resonance imaging and aspiration cytology. Acta Radiol. 2007;48(10):1049–51.CrossRefPubMedGoogle Scholar
  32. 32.
    Lee JC, Fletcher CD. Malignant fat-forming solitary fibrous tumor (so-called “lipomatous hemangiopericytoma”): clinicopathologic analysis of 14 cases. Am J Surg Pathol. 2011;35(8):1177–85.CrossRefPubMedGoogle Scholar
  33. 33.
    Tani E, Wejde J, Astrom K, Wingmo IL, Larsson O, Haglund F. FNA cytology of solitary fibrous tumors and the diagnostic value of STAT6 immunocytochemistry. Cancer. 2018;126(1):36–43.Google Scholar
  34. 34.
    Domanski HA. Fine-needle aspiration smears from lipomatous hemangiopericytoma need not be confused with myxoid liposarcoma. Diagn Cytopathol. 2003;29(5):287–91.CrossRefPubMedGoogle Scholar
  35. 35.
    Dash RC, Liu K, Sheafor DH, Dodd LG. Fine-needle aspiration findings in idiopathic retroperitoneal fibrosis. Diagn Cytopathol. 1999;21(1):22–6.CrossRefPubMedGoogle Scholar
  36. 36.
    Jadusingh IH. Fine needle aspiration cytology of fibrous hamartoma of infancy. Acta Cytol. 1997;41(4 Suppl):1391–3.CrossRefPubMedGoogle Scholar
  37. 37.
    Morency E, Laskin W, Lin X. Cytologic and histologic features of pleomorphic undifferentiated sarcoma arising in a hybrid Hemosiderotic Fibrolipomatous tumor and pleomorphic Hyalinizing Angiectatic tumor: report of an unusual case with a literature review. Acta Cytol. 2015;59(6):493–7.CrossRefPubMedGoogle Scholar
  38. 38.
    Marino-Enriquez A, Fletcher CD, Dal Cin P, Hornick JL. Dedifferentiated liposarcoma with “homologous” lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. Am J Surg Pathol. 2010;34(8):1122–31.CrossRefPubMedGoogle Scholar
  39. 39.
    Chen BJ, Marino-Enriquez A, Fletcher CD, Hornick JL. Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications. Am J Surg Pathol. 2012;36(8):1119–28.CrossRefPubMedGoogle Scholar
  40. 40.
    Wei S, Henderson-Jackson E, Qian X, Bui MM. Soft tissue tumor immunohistochemistry update: illustrative examples of diagnostic pearls to avoid pitfalls. Arch Pathol Lab Med. 2017;141(8):1072–91.CrossRefPubMedGoogle Scholar
  41. 41.
    Doyle LA, Vivero M, Fletcher CD, Mertens F, Hornick JL. Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Modern Pathol. 2014;27(3):390–5.CrossRefGoogle Scholar
  42. 42.
    Binh MB, Sastre-Garau X, Guillou L, et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol. 2005;29(10):1340–7.CrossRefPubMedGoogle Scholar
  43. 43.
    Clay MR, Martinez AP, Weiss SW, Edgar MA. MDM2 and CDK4 immunohistochemistry: should it be used in problematic differentiated Lipomatous tumors?: a new perspective. Am J Surg Pathol. 2016;40(12):1647–52.CrossRefPubMedGoogle Scholar
  44. 44.
    Dujardin F, Binh MB, Bouvier C, et al. MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. Mod Pathol. 2011;24(5):624–37.CrossRefPubMedGoogle Scholar
  45. 45.
    Anderson WJ, Hornick JL. Immunohistochemical correlates of recurrent genetic alterations in sarcomas. Genes Chromosomes Cancer. 2019;58(2):111–23.CrossRefPubMedGoogle Scholar
  46. 46.
    Sioletic S, Dal Cin P, Fletcher CD, Hornick JL. Well-differentiated and dedifferentiated liposarcomas with prominent myxoid stroma: analysis of 56 cases. Histopathology. 2013;62(2):287–93.CrossRefPubMedGoogle Scholar
  47. 47.
    Weaver J, Rao P, Goldblum JR, et al. Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma? Mod Pathol. 2010;23(10):1301–6.CrossRefPubMedGoogle Scholar
  48. 48.
    Wakely PE Jr, Bos GD, Mayerson J. The cytopathology of soft tissue mxyomas: ganglia, juxta-articular myxoid lesions, and intramuscular myxoma. Am J Clin Pathol. 2005;123(6):858–65.CrossRefPubMedGoogle Scholar
  49. 49.
    Yang EJ, Hornick JL, Qian X. Fine-needle aspiration of soft tissue perineurioma: a comparative analysis of cytomorphology and immunohistochemistry with benign and malignant mimics. Cancer Cytopathol. 2016;124(9):651–8.CrossRefPubMedGoogle Scholar
  50. 50.
    Minami R, Yamamoto T, Tsukamoto R, Maeda S. Fine needle aspiration cytology of the malignant variant of ossifying fibromyxoid tumor of soft parts: a case report. Acta Cytol. 2001;45(5):745–55.CrossRefPubMedGoogle Scholar
  51. 51.
    Wang G, Tucker T, Ng TL, Villamil CF, Hayes MM. Fine-needle aspiration of soft tissue myoepithelioma. Diagn Cytopathol. 2016;44(2):152–5.CrossRefPubMedGoogle Scholar
  52. 52.
    Marino-Enriquez A, Nascimento AF, Ligon AH, Liang C, Fletcher CD. Atypical spindle cell Lipomatous tumor: clinicopathologic characterization of 232 cases demonstrating a morphologic Spectrum. Am J Surg Pathol. 2017;41(2):234–44.CrossRefPubMedGoogle Scholar
  53. 53.
    Willems SM, Mohseny AB, Balog C, et al. Cellular/intramuscular myxoma and grade I myxofibrosarcoma are characterized by distinct genetic alterations and specific composition of their extracellular matrix. J Cell Mol Med. 2009;13(7):1291–301.CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Colin P, Lagace R, Caillaud JM, Sastre-Garau X, Klijanienko J. Fine-needle aspiration in myxofibrosarcoma: experience of Institut Curie. Diagn Cytopathol. 2010;38(5):343–6.CrossRefPubMedGoogle Scholar
  55. 55.
    Olson MT, Ali SZ. Myxofibrosarcoma: cytomorphologic findings and differential diagnosis on fine needle aspiration. Acta Cytol. 2012;56(1):15–24.CrossRefPubMedGoogle Scholar
  56. 56.
    Domanski HA, Mertens F, Panagopoulos I, Akerman M. Low-grade fibromyxoid sarcoma is difficult to diagnose by fine needle aspiration cytology: a cytomorphological study of eight cases. Cytopathology. 2009;20(5):304–14.CrossRefPubMedGoogle Scholar
  57. 57.
    Jakowski JD, Wakely PE Jr. Cytopathology of extraskeletal myxoid chondrosarcoma: report of 8 cases. Cancer. 2007;111(5):298–305.CrossRefPubMedGoogle Scholar
  58. 58.
    Santos F, Martins C, Lemos MM. Fine-needle aspiration features of extraskeletal myxoid chondrosarcoma: a study of cytological and molecular features. Diagn Cytopathol. 2018;46(11):950–7.CrossRefPubMedGoogle Scholar
  59. 59.
    Wickham MQ, Youens KE, Dodd LG. Acral myxoinflammatory fibroblastic sarcoma fine needle aspiration: a case report. Diagn Cytopathol. 2012;40(Suppl 2):E144–8.CrossRefPubMedGoogle Scholar
  60. 60.
    Domanski HA, Akerman M, Engellau J, Gustafson P, Mertens F, Rydholm A. Fine-needle aspiration of neurilemoma (schwannoma). A clinicocytopathologic study of 116 patients. Diagn Cytopathol. 2006;34(6):403–12.CrossRefPubMedGoogle Scholar
  61. 61.
    Klijanienko J, Caillaud JM, Lagace R. Cytohistologic correlations in schwannomas (neurilemmomas), including “ancient,” cellular, and epithelioid variants. Diagn Cytopathol. 2006;34(8):517–22.CrossRefPubMedGoogle Scholar
  62. 62.
    Lee JC, Wu JM, Liau JY, et al. Cytopathologic features of epithelioid inflammatory myofibroblastic sarcoma with correlation of histopathology, immunohistochemistry, and molecular cytogenetic analysis. Cancer Cytopathol. 2015;123(8):495–504.CrossRefPubMedGoogle Scholar
  63. 63.
    Doyle LA, Wang WL, Dal Cin P, et al. MUC4 is a sensitive and extremely useful marker for sclerosing epithelioid fibrosarcoma: association with FUS gene rearrangement. Am J Surg Pathol. 2012;36(10):1444–51.CrossRefPubMedGoogle Scholar
  64. 64.
    Flucke U, Tops BB, Verdijk MA, et al. NR4A3 rearrangement reliably distinguishes between the clinicopathologically overlapping entities myoepithelial carcinoma of soft tissue and cellular extraskeletal myxoid chondrosarcoma. Virchows Arch. 2012;460(6):621–8.CrossRefPubMedPubMedCentralGoogle Scholar
  65. 65.
    Downs-Kelly E, Goldblum JR, Patel RM, et al. The utility of fluorescence in situ hybridization (FISH) in the diagnosis of myxoid soft tissue neoplasms. Am J Surg Pathol. 2008;32(1):8–13.CrossRefPubMedGoogle Scholar
  66. 66.
    Domanski HA, Gustafson P. Cytologic features of primary, recurrent, and metastatic dermatofibrosarcoma protuberans. Cancer. 2002;96(6):351–61.CrossRefPubMedGoogle Scholar
  67. 67.
    Evans HL. Low-grade fibromyxoid sarcoma. A report of two metastasizing neoplasms having a deceptively benign appearance. Am J Clin Pathol. 1987;88(5):615–9.CrossRefPubMedGoogle Scholar
  68. 68.
    Guillou L, Benhattar J, Gengler C, et al. Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group. Am J Surg Pathol. 2007;31(9):1387–402.CrossRefPubMedGoogle Scholar
  69. 69.
    Huang HY, Lal P, Qin J, Brennan MF, Antonescu CR. Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. Hum Pathol. 2004;35(5):612–21.CrossRefPubMedGoogle Scholar
  70. 70.
    Oda Y, Takahira T, Kawaguchi K, et al. Low-grade fibromyxoid sarcoma versus low-grade myxofibrosarcoma in the extremities and trunk. A comparison of clinicopathological and immunohistochemical features. Histopathology. 2004;45(1):29–38.CrossRefPubMedGoogle Scholar
  71. 71.
    Nasrallah MP, Nasrallah IM, Yu GH. Fine-needle aspiration of superficial myxoid neurofibroma in the region of the breast. Diagn Cytopathol. 2015;43(5):427–31.CrossRefPubMedGoogle Scholar
  72. 72.
    Allison DB, Wakely PE Jr, Siddiqui MT, Ali SZ. Nodular fasciitis: a frequent diagnostic pitfall on fine-needle aspiration. Cancer Cytopathol. 2017;125(1):20–9.CrossRefPubMedGoogle Scholar
  73. 73.
    Tao LC, Davidson DD. Aspiration biopsy cytology of smooth muscle tumors. A cytologic approach to the differentiation between leiomyosarcoma and leiomyoma. Acta Cytol. 1993;37(3):300–8.PubMedGoogle Scholar
  74. 74.
    Rohit M, Bhatt A, Cruise M, Wearsch PA, Goldblum JR, Sturgis CD. Endoscopic ultrasound FNA: an illustrated review of spindle cell neoplasms of the upper gastrointestinal tract including a novel case of gastric plexiform fibromyxoma. Diagn Cytopathol. 2018;46(9):730–8.CrossRefPubMedGoogle Scholar
  75. 75.
    Domanski HA, Carlen B, Sloth M, Rydholm A. Elastofibroma dorsi has distinct cytomorphologic features, making diagnostic surgical biopsy unnecessary: cytomorphologic study with clinical, radiologic, and electron microscopic correlations. Diagn Cytopathol. 2003;29(6):327–33.CrossRefPubMedGoogle Scholar
  76. 76.
    Owens CL, Sharma R, Ali SZ. Deep fibromatosis (desmoid tumor): cytopathologic characteristics, clinicoradiologic features, and immunohistochemical findings on fine-needle aspiration. Cancer. 2007;111(3):166–72.CrossRefPubMedGoogle Scholar
  77. 77.
    Rege TA, Madan R, Qian X. Long fascicular tissue fragments in desmoid fibromatosis by fine needle aspiration: a new cytologic feature. Diagn Cytopathol. 2012;40(1):45–7.CrossRefPubMedGoogle Scholar
  78. 78.
    Stoll LM, Li QK. Cytology of fine-needle aspiration of inflammatory myofibroblastic tumor. Diagn Cytopathol. 2011;39(9):663–72.CrossRefPubMedGoogle Scholar
  79. 79.
    Klijanienko J, Caillaud JM, Lagace R. Fine-needle aspiration of primary and recurrent dermatofibrosarcoma protuberans. Diagn Cytopathol. 2004;30(4):261–5.CrossRefPubMedGoogle Scholar
  80. 80.
    Clayton AC, Salomao DR, Keeney GL, Nascimento AG. Solitary fibrous tumor: a study of cytologic features of six cases diagnosed by fine-needle aspiration. Diagn Cytopathol. 2001;25(3):172–6.CrossRefPubMedGoogle Scholar
  81. 81.
    Domanski HA, Akerman M, Rissler P, Gustafson P. Fine-needle aspiration of soft tissue leiomyosarcoma: an analysis of the most common cytologic findings and the value of ancillary techniques. Diagn Cytopathol. 2006;34(9):597–604.CrossRefPubMedGoogle Scholar
  82. 82.
    McGee RS Jr, Ward WG, Kilpatrick SE. Malignant peripheral nerve sheath tumor: a fine-needle aspiration biopsy study. Diagn Cytopathol. 1997;17(4):298–305.CrossRefPubMedGoogle Scholar
  83. 83.
    Wakely PE Jr, Ali SZ, Bishop JA. The cytopathology of malignant peripheral nerve sheath tumor : a report of 55 fine-needle aspiration cases. Cancer Cytopathol. 2012;120(5):334–41.CrossRefPubMedGoogle Scholar
  84. 84.
    Kilpatrick SE, Teot LA, Stanley MW, Ward WG, Savage PD, Geisinger KR. Fine-needle aspiration biopsy of synovial sarcoma. A cytomorphologic analysis of primary, recurrent, and metastatic tumors. Am J Clin Pathol. 1996;106(6):769–75.CrossRefPubMedGoogle Scholar
  85. 85.
    Klijanienko J, Caillaud JM, Lagace R, Vielh P. Cytohistologic correlations in 56 synovial sarcomas in 36 patients: the Institut Curie experience. Diagn Cytopathol. 2002;27(2):96–102.CrossRefPubMedGoogle Scholar
  86. 86.
    Cantley RL, Cimbaluk D, Reddy V, Iacusso C, Gattuso P. Fine-needle aspiration diagnosis of a metastatic adult sclerosing rhabdomyosarcoma in a lymph node. Diagn Cytopathol. 2010;38(10):761–4.PubMedGoogle Scholar
  87. 87.
    Fletcher C, Bridge JA, Hogendoorn PCW, Mertens F. WHO classification of tumours of soft tissue and bone. Lyon: IARC Press; 2013.Google Scholar
  88. 88.
    Brown FM, Fletcher CD. Problems in grading soft tissue sarcomas. Am J Clin Pathol. 2000;114(Suppl):S82–9.PubMedGoogle Scholar
  89. 89.
    Palmer HE, Mukunyadzi P, Culbreth W, Thomas JR. Subgrouping and grading of soft-tissue sarcomas by fine-needle aspiration cytology: a histopathologic correlation study. Diagn Cytopathol. 2001;24(5):307–16.CrossRefPubMedGoogle Scholar
  90. 90.
    Roitman PD, Farfalli GL, Ayerza MA, Muscolo DL, Milano FE, Aponte-Tinao LA. Is needle biopsy clinically useful in preoperative grading of central chondrosarcoma of the pelvis and long bones? Clin Orthop Relat Res. 2017;475(3):808–14.CrossRefPubMedGoogle Scholar
  91. 91.
    Guiter GE, Gamboni MM, Zakowski MF. The cytology of extraskeletal Ewing sarcoma. Cancer. 1999;87(3):141–8.CrossRefPubMedGoogle Scholar
  92. 92.
    Klijanienko J, Couturier J, Bourdeaut F, et al. Fine-needle aspiration as a diagnostic technique in 50 cases of primary Ewing sarcoma/peripheral neuroectodermal tumor. Institut Curie’s experience. Diagn Cytopathol. 2012;40(1):19–25.CrossRefPubMedGoogle Scholar
  93. 93.
    Russell-Goldman E, Hornick JL, Qian X, Jo VY. NKX2.2 immunohistochemistry in the distinction of Ewing sarcoma from cytomorphologic mimics: diagnostic utility and pitfalls. Cancer Cytopathol. 2018;126(11):942–9.CrossRefPubMedGoogle Scholar
  94. 94.
    Crapanzano JP, Cardillo M, Lin O, Zakowski MF. Cytology of desmoplastic small round cell tumor. Cancer. 2002;96(1):21–31.CrossRefPubMedGoogle Scholar
  95. 95.
    Leca LB, Vieira J, Teixeira MR, Monteiro P. Desmoplastic small round cell tumor: diagnosis by fine-needle aspiration cytology. Acta Cytol. 2012;56(5):576–80.CrossRefPubMedGoogle Scholar
  96. 96.
    Klijanienko J, Colin P, Couturier J, et al. Fine-needle aspiration in desmoplastic small round cell tumor: a report of 10 new tumors in 8 patients with clinicopathological and molecular correlations with review of the literature. Cancer Cytopathol. 2014;122(5):386–93.CrossRefPubMedGoogle Scholar
  97. 97.
    Seidal T, Walaas L, Kindblom LG, Angervall L. Cytology of embryonal rhabdomyosarcoma: a cytologic, light microscopic, electron microscopic, and immunohistochemical study of seven cases. Diagn Cytopathol. 1988;4(4):292–9.CrossRefPubMedGoogle Scholar
  98. 98.
    Udayakumar AM, Sundareshan TS, Appaji L, Biswas S, Mukherjee G. Rhabdomyosarcoma: cytogenetics of five cases using fine-needle aspiration samples and review of the literature. Ann Genet. 2002;45(1):33–7.CrossRefPubMedGoogle Scholar
  99. 99.
    de Almeida M, Stastny JF, Wakely PE Jr, Frable WJ. Fine-needle aspiration biopsy of childhood rhabdomyosarcoma: reevaluation of the cytologic criteria for diagnosis. Diagn Cytopathol. 1994;11(3):231–6.CrossRefPubMedGoogle Scholar
  100. 100.
    Valencerina Gopez E, Dauterman J, Layfield LJ. Fine-needle aspiration biopsy of alveolar rhabdomyosarcoma of the parotid: a case report and review of the literature. Diagn Cytopathol. 2001;24(4):249–52.CrossRefPubMedGoogle Scholar
  101. 101.
    Chebib I, Jo VY. Round cell sarcoma with CIC-DUX4 gene fusion: discussion of the distinctive cytomorphologic, immunohistochemical, and molecular features in the differential diagnosis of round cell tumors. Cancer Cytopathol. 2016;124(5):350–61.CrossRefPubMedGoogle Scholar
  102. 102.
    Kao YC, Owosho AA, Sung YS, et al. BCOR-CCNB3 fusion positive sarcomas: a clinicopathologic and molecular analysis of 36 cases with comparison to morphologic spectrum and clinical behavior of other round cell sarcomas. Am J Surg Pathol. 2018;42(5):604–15.PubMedPubMedCentralGoogle Scholar
  103. 103.
    Silverman JF, Landreneau RJ, Sturgis CD, et al. Small-cell variant of synovial sarcoma: fine-needle aspiration with ancillary features and potential diagnostic pitfalls. Diagn Cytopathol. 2000;23(2):118–23.CrossRefPubMedGoogle Scholar
  104. 104.
    Ali RH, Lee CH, Hayes MM. Metastatic small cell osteosarcoma to the liver: a diagnostic pitfall for fine-needle aspiration cytology. Diagn Cytopathol. 2014;42(2):161–4.CrossRefPubMedGoogle Scholar
  105. 105.
    Bishop JA, Shum CH, Sheth S, Wakely PE Jr, Ali SZ. Small cell osteosarcoma: cytopathologic characteristics and differential diagnosis. Am J Clin Pathol. 2010;133(5):756–61.CrossRefPubMedGoogle Scholar
  106. 106.
    Trembath DG, Dash R, Major NM, Dodd LG. Cytopathology of mesenchymal chondrosarcomas: a report and comparison of four patients. Cancer. 2003;99(4):211–6.CrossRefPubMedGoogle Scholar
  107. 107.
    Szadowska A, Lasota J. Fine needle aspiration cytology of myxoid liposarcoma; a study of 18 tumours. Cytopathology. 1993;4(2):99–106.CrossRefPubMedGoogle Scholar
  108. 108.
    Shield PW, Crous H. Fine-needle aspiration cytology of Merkel cell carcinoma-a review of 69 cases. Diagn Cytopathol. 2014;42(11):924–8.CrossRefPubMedGoogle Scholar
  109. 109.
    Cipolletta Campanile A, Malzone MG, Sanna V, et al. Cytological and immunocytochemical features of Merkel cell carcinoma on fine needle cytology samples: a study of 22 cases. Endocr Pathol. 2015;26(3):243–9.CrossRefPubMedGoogle Scholar
  110. 110.
    Ojha SS, Kothari KS, Naik LP, Fernandes GC, Rangwala S, Agnihotri MA. Dysplastic megakaryocytes and eosinophilic precursors in the diagnosis of myeloid sarcoma on lymph node fine-needle aspiration cytology: a case series. Acta Cytol. 2012;56(3):325–9.CrossRefPubMedGoogle Scholar
  111. 111.
    Bishop JA, French CA, Ali SZ. Cytopathologic features of NUT midline carcinoma: a series of 26 specimens from 13 patients. Cancer Cytopathol. 2016;124(12):901–8.CrossRefPubMedGoogle Scholar
  112. 112.
    Thiesse P, Hany MA, Combaret V, Ranchere-Vince D, Bouffet E, Bergeron C. Assessment of percutaneous fine needle aspiration cytology as a technique to provide diagnostic and prognostic information in neuroblastoma. Eur J Cancer. 2000;36(12):1544–51.CrossRefPubMedGoogle Scholar
  113. 113.
    Al-Za’abi AM, Boerner SL, Geddie WB. Fine needle aspiration cytology of a differentiated neuroblastoma presenting as a scalp lesion in an adult: a case report. Diagn Cytopathol. 2008;36(2):133–5.CrossRefPubMedGoogle Scholar
  114. 114.
    Hall BJ, Schmidt RL, Sharma RR, Layfield LJ. Fine-needle aspiration cytology for the diagnosis of metastatic melanoma: systematic review and meta-analysis. Am J Clin Pathol. 2013;140(5):635–42.CrossRefPubMedGoogle Scholar
  115. 115.
    Fernandez-Pineda I, Cabello R, Garcia-Canton JA, et al. Fine-needle aspiration cytopathology in the diagnosis of Wilms tumor. Clin Transl Oncol. 2011;13(11):809–11.CrossRefPubMedGoogle Scholar
  116. 116.
    Szuhai K, de Jong D, Leung WY, Fletcher CD, Hogendoorn PC. Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma. J Pathol. 2014;232(3):300–7.CrossRefPubMedGoogle Scholar
  117. 117.
    Foo WC, Cruise MW, Wick MR, Hornick JL. Immunohistochemical staining for TLE1 distinguishes synovial sarcoma from histologic mimics. Am J Clin Pathol. 2011;135(6):839–44.CrossRefPubMedGoogle Scholar
  118. 118.
    Arnold MA, Schoenfield L, Limketkai BN, Arnold CA. Diagnostic pitfalls of differentiating desmoplastic small round cell tumor (DSRCT) from Wilms tumor (WT): overlapping morphologic and immunohistochemical features. Am J Surg Pathol. 2014;38(9):1220–6.CrossRefPubMedGoogle Scholar
  119. 119.
    Hung YP, Fletcher CD, Hornick JL. Evaluation of ETV4 and WT1 expression in CIC-rearranged sarcomas and histologic mimics. Mod Pathol. 2016;29(11):1324–34.CrossRefPubMedGoogle Scholar
  120. 120.
    Conner JR, Hornick JL. SATB2 is a novel marker of osteoblastic differentiation in bone and soft tissue tumours. Histopathology. 2013;63(1):36–49.CrossRefPubMedGoogle Scholar
  121. 121.
    Machado I, Navarro S, Picci P, Llombart-Bosch A. The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such as Ewing sarcomas and chondrosarcomas. Pathol Res Pract. 2016;212(9):811–6.CrossRefPubMedGoogle Scholar
  122. 122.
    Bridge JA, Fidler ME, Neff JR, et al. Adamantinoma-like Ewing’s sarcoma: genomic confirmation, phenotypic drift. Am J Surg Pathol. 1999;23(2):159–65.CrossRefPubMedGoogle Scholar
  123. 123.
    Lilo MT, Bishop JA, Olson MT, Ali SZ. Adamantinoma-like Ewing sarcoma of the parotid gland: cytopathologic findings and differential diagnosis. Diagn Cytopathol. 2018;46(3):263–6.CrossRefPubMedGoogle Scholar
  124. 124.
    Thway K, Fisher C. Mesenchymal tumors with EWSR1 gene rearrangements. Surg Pathol Clin. 2019;12(1):165–90.CrossRefPubMedGoogle Scholar
  125. 125.
    Wieczorek TJ, Krane JF, Domanski HA, et al. Cytologic findings in granular cell tumors, with emphasis on the diagnosis of malignant granular cell tumor by fine-needle aspiration biopsy. Cancer. 2001;93(6):398–408.CrossRefPubMedGoogle Scholar
  126. 126.
    Gu M, Nguyen PT, Cao S, Lin F. Diagnosis of gastric glomus tumor by endoscopic ultrasound-guided fine needle aspiration biopsy. A case report with cytologic, histologic and immunohistochemical studies. Acta Cytol. 2002;46(3):560–6.CrossRefPubMedGoogle Scholar
  127. 127.
    Rau AR, Kini H, Verghese R. Tigroid background in fine-needle aspiration cytology of clear cell sarcoma. Diagn Cytopathol. 2006;34(5):355–7.CrossRefPubMedGoogle Scholar
  128. 128.
    Cardillo M, Zakowski MF, Lin O. Fine-needle aspiration of epithelioid sarcoma: cytology findings in nine cases. Cancer. 2001;93(4):246–51.CrossRefPubMedGoogle Scholar
  129. 129.
    Wakely PE Jr, McDermott JE, Ali SZ. Cytopathology of alveolar soft part sarcoma: a report of 10 cases. Cancer. 2009;117(6):500–7.PubMedGoogle Scholar
  130. 130.
    Akhtar M, Kfoury H, Haider A, Sackey K, Ali MA. Fine-needle aspiration biopsy diagnosis of extrarenal malignant rhabdoid tumor. Diagn Cytopathol. 1994;11(3):271–6.CrossRefPubMedGoogle Scholar
  131. 131.
    Janovitz T, Sholl LM, Qian X. Cytopathologic features of SMARCA4-deficient neoplasms (abstract). Mod Pathol. 2019; 132:1–138Google Scholar
  132. 132.
    Sauter JL, Graham RP, Larsen BT, Jenkins SM, Roden AC, Boland JM. SMARCA4-deficient thoracic sarcoma: a distinctive clinicopathological entity with undifferentiated rhabdoid morphology and aggressive behavior. Mod Pathol. 2017;30(10):1422–32.CrossRefPubMedGoogle Scholar
  133. 133.
    Evans HL, Raymond AK, Ayala AG. Vascular tumors of bone: a study of 17 cases other than ordinary hemangioma, with an evaluation of the relationship of hemangioendothelioma of bone to epithelioid hemangioma, epithelioid hemangioendothelioma, and high-grade angiosarcoma. Hum Pathol. 2003;34(7):680–9.CrossRefPubMedGoogle Scholar
  134. 134.
    Baehner F, Sudilovsky D. Fine needle aspiration cytology of intraoral epithelioid hemangioma. A report of two cases. Acta Cytol. 2003;47(2):275–80.CrossRefPubMedGoogle Scholar
  135. 135.
    Kilpatrick SE, Koplyay PD, Ward WG, Richards F 2nd. Epithelioid hemangioendothelioma of bone and soft tissue: a fine-needle aspiration biopsy study with histologic and immunohistochemical confirmation. Diagn Cytopathol. 1998;19(1):38–43.CrossRefPubMedGoogle Scholar
  136. 136.
    Wakely PE Jr, Frable WJ, Kneisl JS. Aspiration cytopathology of epithelioid angiosarcoma. Cancer. 2000;90(4):245–51.CrossRefPubMedGoogle Scholar
  137. 137.
    Pohar-Marinsek Z, Lamovec J. Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses. Cytopathology. 2010;21(5):311–9.CrossRefPubMedGoogle Scholar
  138. 138.
    Hornick JL, Fletcher CD. Pseudomyogenic hemangioendothelioma: a distinctive, often multicentric tumor with indolent behavior. Am J Surg Pathol. 2011;35(2):190–201.CrossRefPubMedGoogle Scholar
  139. 139.
    Pradhan D, Schoedel K, McGough RL, Ranganathan S, Rao UNM. Pseudomyogenic hemangioendothelioma of skin, bone and soft tissue-a clinicopathological, immunohistochemical, and fluorescence in situ hybridization study. Hum Pathol. 2018;71:126–34.CrossRefPubMedGoogle Scholar
  140. 140.
    Doyle LA, Nelson D, Heinrich MC, Corless CL, Hornick JL. Loss of succinate dehydrogenase subunit B (SDHB) expression is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours: a comprehensive genotype-phenotype correlation study. Histopathology. 2012;61(5):801–9.CrossRefPubMedGoogle Scholar
  141. 141.
    Dodd LG, Scully S, Layfield LJ. Fine-needle aspiration of epithelioid malignant peripheral nerve sheath tumor (epithelioid malignant schwannoma). Diagn Cytopathol. 1997;17(3):200–4.CrossRefPubMedGoogle Scholar
  142. 142.
    Jiwani S, Gokden M, Lindberg M, Ali S, Jeffus S. Fine-needle aspiration cytology of epithelioid malignant peripheral nerve sheath tumor: a case report and review of the literature. Diagn Cytopathol. 2016;44(3):226–31.CrossRefPubMedGoogle Scholar
  143. 143.
    Park IA, Kim JS, Ham EK. Fine needle aspiration cytology of gastric epithelioid leiomyosarcoma metastasized to the liver. A case report. Acta Cytol. 1997;41(6):1801–6.CrossRefPubMedGoogle Scholar
  144. 144.
    Weber MH, Kilpatrick SE, Bergman S. The cytologic diagnosis of epithelioid myxofibrosarcoma: a case report. Diagn Cytopathol. 2012;40(Suppl 2):E140–3.CrossRefPubMedGoogle Scholar
  145. 145.
    Doyle LA, Fletcher CD, Hornick JL. Nuclear expression of CAMTA1 distinguishes epithelioid hemangioendothelioma from histologic mimics. Am J Surg Pathol. 2016;40(1):94–102.CrossRefPubMedGoogle Scholar
  146. 146.
    Argani P, Aulmann S, Illei PB, et al. A distinctive subset of PEComas harbors TFE3 gene fusions. Am J Surg Pathol. 2010;34(10):1395–406.CrossRefPubMedGoogle Scholar
  147. 147.
    Antonescu CR, Le Loarer F, Mosquera JM, et al. Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma. Genes Chromosomes Cancer. 2013;52(8):775–84.CrossRefPubMedPubMedCentralGoogle Scholar
  148. 148.
    Chamberlain BK, McClain CM, Gonzalez RS, Coffin CM, Cates JM. Alveolar soft part sarcoma and granular cell tumor: an immunohistochemical comparison study. Hum Pathol. 2014;45(5):1039–44.CrossRefPubMedGoogle Scholar
  149. 149.
    Hung YP, Fletcher CD, Hornick JL. FOSB is a useful diagnostic marker for Pseudomyogenic Hemangioendothelioma. Am J Surg Pathol. 2017;41(5):596–606.CrossRefPubMedGoogle Scholar
  150. 150.
    Ortins-Pina A, Llamas-Velasco M, Turpin S, Soares-de-Almeida L, Filipe P, Kutzner H. FOSB immunoreactivity in endothelia of epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia). J Cutan Pathol. 2018;45(6):395–402.CrossRefPubMedGoogle Scholar
  151. 151.
    Marino-Enriquez A, Wang WL, Roy A, et al. Epithelioid inflammatory myofibroblastic sarcoma: an aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK. Am J Surg Pathol. 2011;35(1):135–44.CrossRefPubMedGoogle Scholar
  152. 152.
    Hollmann TJ, Hornick JL. INI1-deficient tumors: diagnostic features and molecular genetics. Am J Surg Pathol. 2011;35(10):e47–63.CrossRefPubMedGoogle Scholar
  153. 153.
    Hornick JL. Introduction: tumor classification and immunohistochemistry. In: Hornick JL, editor. Practical soft tissue pathology: a diagnostic approach. 2nd ed. Philadelphia: Elsevier; 2019. p. 1–14.Google Scholar
  154. 154.
    Horvai A, Dashti NK, Rubin BP, et al. Genetic and molecular reappraisal of spindle cell adamantinoma of bone reveals a small subset of misclassified intraosseous synovial sarcoma. Mod Pathol. 2019;32(2):231–41.CrossRefPubMedGoogle Scholar
  155. 155.
    Zhang Y, Paz Mejia A, Temple HT, Trent J, Rosenberg AE. Squamous cell carcinoma arising in dedifferentiated chondrosarcoma proved by isocitrate dehydrogenase mutation analysis. Hum Pathol. 2014;45(7):1541–5.CrossRefPubMedGoogle Scholar
  156. 156.
    Xie J, Pu C, Silverman JF. Fine-needle aspiration cytology of intranodal palisaded myofibroblastoma of the inguinal lymph node. Acta Cytol. 2016;60(1):89–92.CrossRefPubMedGoogle Scholar
  157. 157.
    Hornick JL. Subclassification of pleomorphic sarcomas: how and why should we care? Ann Diagn Pathol. 2018;37:118–24.CrossRefPubMedGoogle Scholar
  158. 158.
    Carvalho SD, Pissaloux D, Crombe A, Coindre JM, Le Loarer F. Pleomorphic sarcomas: the state of the art. Surg Pathol Clin. 2019;12(1):63–105.CrossRefPubMedGoogle Scholar
  159. 159.
    Lopez-Rios F, Alberti N, Perez-Barrios A, de Agustin PP. Fine-needle aspiration of pleomorphic lipoma. Diagn Cytopathol. 2001;24(4):296–7.CrossRefPubMedGoogle Scholar
  160. 160.
    Klijanienko J, Caillaud JM, Lagace R, Vielh P. Fine-needle aspiration of leiomyosarcoma: a correlative cytohistopathological study of 96 tumors in 68 patients. Diagn Cytopathol. 2003;28(3):119–25.CrossRefPubMedGoogle Scholar
  161. 161.
    Pohar-Marinsek Z, Bracko M. Rhabdomyosarcoma. Cytomorphology, subtyping and differential diagnostic dilemmas. Acta Cytol. 2000;44(4):524–32.CrossRefPubMedGoogle Scholar
  162. 162.
    Klijanienko J, Caillaud JM, Orbach D, et al. Cyto-histological correlations in primary, recurrent and metastatic rhabdomyosarcoma: the Institut Curie’s experience. Diagn Cytopathol. 2007;35(8):482–7.CrossRefPubMedGoogle Scholar
  163. 163.
    Nicol KK, Ward WG, Savage PD, Kilpatrick SE. Fine-needle aspiration biopsy of skeletal versus extraskeletal osteosarcoma. Cancer. 1998;84(3):176–85.CrossRefPubMedGoogle Scholar
  164. 164.
    Klijanienko J, Caillaud JM, Lagace R, Vielh P. Cytohistologic correlations in angiosarcoma including classic and epithelioid variants: Institut Curie’s experience. Diagn Cytopathol. 2003;29(3):140–5.CrossRefPubMedGoogle Scholar
  165. 165.
    Rinas AC, Ward WG, Kilpatrick SE. Potential sampling error in fine needle aspiration biopsy of dedifferentiated chondrosarcoma: a report of 4 cases. Acta Cytol. 2005;49(5):554–9.CrossRefPubMedGoogle Scholar
  166. 166.
    Olson MT, Wakely PE Jr, Weber K, Siddiqui MT, Ali SZ. Postradiation sarcoma: morphological findings on fine-needle aspiration with clinical correlation. Cancer Cytopathol. 2012;120(5):351–7.CrossRefPubMedGoogle Scholar
  167. 167.
    Fanning CV, Sneige NS, Carrasco CH, Ayala AG, Murray JA, Raymond AK. Fine needle aspiration cytology of chondroblastoma of bone. Cancer. 1990;65(8):1847–63.CrossRefPubMedGoogle Scholar
  168. 168.
    Kilpatrick SE, Pike EJ, Geisinger KR, Ward WG. Chondroblastoma of bone: use of fine-needle aspiration biopsy and potential diagnostic pitfalls. Diagn Cytopathol. 1997;16(1):65–71.CrossRefPubMedGoogle Scholar
  169. 169.
    VandenBussche CJ, Sathiyamoorthy S, Wakely PE Jr, Ali SZ. Chondroblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on FNA. Cancer Cytopathol. 2016;124(7):493–500.CrossRefPubMedGoogle Scholar
  170. 170.
    Schaefer IM, Fletcher JA, Nielsen GP, et al. Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy. Cancer Cytopathol. 2018;126(8):552–66.CrossRefPubMedPubMedCentralGoogle Scholar
  171. 171.
    Huang EC, Ghazikhanian V, Qian X. Giant cell-rich osteosarcoma of the parotid gland: an exceptionally rare entity at an unusual site. Diagn Cytopathol. 2016;44(12):1107–11.CrossRefPubMedGoogle Scholar
  172. 172.
    Cardona DM, Dodd LG. Bone cytology: a realistic approach for clinical use. Surg Pathol Clin. 2012;5(1):79–100.CrossRefPubMedGoogle Scholar
  173. 173.
    Kilpatrick SE. Fine needle aspiration biopsy of Langerhans cell histiocytosis of bone: are ancillary studies necessary for a “definitive diagnosis”? Acta Cytol. 1998;42(3):820–3.PubMedGoogle Scholar
  174. 174.
    Shanmugam V, Craig JW, Hornick JL, Morgan EA, Pinkus GS, Pozdnyakova O. Cyclin D1 is expressed in neoplastic cells of Langerhans cell histiocytosis but not reactive Langerhans cell proliferations. Am J Surg Pathol. 2017;41(10):1390–6.CrossRefPubMedGoogle Scholar
  175. 175.
    Walaas L, Kindblom LG. Fine-needle aspiration biopsy in the preoperative diagnosis of chordoma: a study of 17 cases with application of electron microscopic, histochemical, and immunocytochemical examination. Hum Pathol. 1991;22(1):22–8.CrossRefPubMedGoogle Scholar
  176. 176.
    Layfield LJ, Liu K, Dodd LG, Olatidoye BA. “Dedifferentiated” chordoma: a case report of the cytomorphologic findings on fine-needle aspiration. Diagn Cytopathol. 1998;19(5):378–81.CrossRefPubMedGoogle Scholar
  177. 177.
    Kay PA, Nascimento AG, Unni KK, Salomao DR. Chordoma. Cytomorphologic findings in 14 cases diagnosed by fine needle aspiration. Acta Cytol. 2003;47(2):202–8.CrossRefPubMedGoogle Scholar
  178. 178.
    Jo VY, Hornick JL, Qian X. Utility of brachyury in distinction of chordoma from cytomorphologic mimics in fine-needle aspiration and core needle biopsy. Diagn Cytopathol. 2014;42(8):647–52.CrossRefPubMedGoogle Scholar
  179. 179.
    Nicol KK, Ward WG, Pike EJ, Geisinger KR, Cappellari JO, Kilpatrick SE. Fine-needle aspiration biopsy of gouty tophi: lessons in cost-effective patient management. Diagn Cytopathol. 1997;17(1):30–5.CrossRefPubMedGoogle Scholar
  180. 180.
    Bhadani PP, Sah SP, Sen R, Singh RK. Diagnostic value of fine needle aspiration cytology in gouty tophi: a report of 7 cases. Acta Cytol. 2006;50(1):101–4.CrossRefPubMedGoogle Scholar
  181. 181.
    O’Connor SM, Wobker SE, Cardona DM, Eward W, Esther RJ, Dodd LG. Iatrogenic lesions of soft tissue and bone. Semin Diagn Pathol. 2017;35(4):208–17.CrossRefPubMedGoogle Scholar
  182. 182.
    Catelas I, Lehoux EA, Ning Z, Figeys D, Baskey SJ, Beaule PE. Differential proteomic analysis of synovial fluid from hip arthroplasty patients with a pseudotumor vs. Periprosthetic osteolysis. J Orthop Res. 2018;36(7):1849–59.CrossRefPubMedGoogle Scholar
  183. 183.
    Agarwal S, Nangia A, Jyotsna PL, Pujani M. Spindle cell lipoma masquerading as lipomatous pleomorphic adenoma: a diagnostic dilemma on fine needle aspiration cytology. J Cytol. 2013;30(1):55–7.CrossRefPubMedPubMedCentralGoogle Scholar
  184. 184.
    Berry AB, Jaffee I, Greenberg M, Eisele DW, Ljung BM. Nodular fasciitis: definitive diagnosis by fine needle aspiration. Acta Cytol. 2016;60(1):19–24.CrossRefPubMedGoogle Scholar
  185. 185.
    Erickson-Johnson MR, Chou MM, Evers BR, et al. Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. Lab Invest. 2011;91(10):1427–33.CrossRefPubMedGoogle Scholar
  186. 186.
    Deshpande V, Rosenberg AE, O’Connell JX, Nielsen GP. Epithelioid angiosarcoma of the bone: a series of 10 cases. Am J Surg Pathol. 2003;27(6):709–16.CrossRefPubMedGoogle Scholar
  187. 187.
    Verbeke SL, Bertoni F, Bacchini P, et al. Distinct histological features characterize primary angiosarcoma of bone. Histopathology. 2011;58(2):254–64.CrossRefPubMedGoogle Scholar
  188. 188.
    Malini K, Gudi NS, Kutty AV, Balakrishna S. Mutational analysis of exostosin 1 and 2 genes in multiple osteochondroma. Indian J Pediatr. 2015;82(7):649–50.CrossRefPubMedGoogle Scholar
  189. 189.
    Crapanzano JP, Ali SZ, Ginsberg MS, Zakowski MF. Chordoma: a cytologic study with histologic and radiologic correlation. Cancer. 2001;93(1):40–51.CrossRefPubMedGoogle Scholar

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Brigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Department of Pathology and Clinical LaboratoriesHospital for Special SurgeryNew YorkUSA

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