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Effects of Soap-Water Wash on Human Epidermal Penetration

  • Hanjiang ZhuEmail author
  • Eui-Chang Jung
  • Christina Phuong
  • Xiaoying Hui
  • Howard I. Maibach
Chapter

Abstract

Epidermal penetration was assayed with four chemicals to elucidate the effect of SC hydration on chemical penetration. Results showed accelerated benzoic acid and paraoxon penetration quickly after surface wash, but reduced penetration of hydroquinone and benzoic acid 30 min postdecontamination. At the end of the experiment, lower hydroquinone penetration, greater paraoxon penetration, and similar levels of benzoic acid and clonidine penetration resulted from surface wash. The observed wash-in effect agrees with the enhancement effect of SC hydration on SC chemical absorption rate.

Keywords

Skin decontamination Percutaneous penetration Wash-in effect Pesticide Stratum corneum 

Notes

Acknowledgments

This research is supported by Defense Threat Reduction Agency (DTRA) Grant: HDTRA1-14-0005 UCSF (BRBAA11-PerC-9-2-0054 – Base).

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Hanjiang Zhu
    • 1
    Email author
  • Eui-Chang Jung
    • 1
    • 2
  • Christina Phuong
    • 1
  • Xiaoying Hui
    • 1
  • Howard I. Maibach
    • 1
  1. 1.Department of DermatologyUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Department of DermatologyGyeongsang National University Changwon HospitalChangwonSouth Korea

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