MicroRNAs in Drosophila Cancer Models

  • Moritz Sander
  • Héctor HerranzEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1167)


MiRNAs are post-transcriptional regulators of gene expression which have been implicated in virtually all biological processes. MiRNAs are frequently dysregulated in human cancers. However, the functional consequences of aberrant miRNA levels are not well understood. Drosophila is emerging as an important in vivo tumor model, especially in the identification of novel cancer genes. Here, we review Drosophila studies which functionally dissect the roles of miRNAs in tumorigenesis. Ultimately, these advances help to understand the implications of miRNA dysregulation in human cancers.


Drosophila Cancer Animal models miRNAs Oncogenic cooperation Bantam let-7 miR-7 miR-8 





Brain tumor


Cancer stem cell








Epidermal growth factor receptor


Germline stem cell


Janus kinase/Signal transducer and activator of transcription proteins




Lethal giant larvae




RNA interference




Suppressor of cytokine signaling at 36E


Yes associated protein





This work was supported by the Novo Nordisk Foundation (grant number NNF0052223), a grant from the Neye Foundation for genetic models for cancer gene discovery, and a grant by Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis’ Legat.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Cellular and Molecular MedicineUniversity of CopenhagenCopenhagenDenmark

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