The Initial Stage of Tumorigenesis in Drosophila Epithelial Tissues

  • Yoichiro TamoriEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1167)


Cancer development originates in a single mutant cell transformed from a normal cell, including further evolution of pro-tumor cells through additional mutations into malignant cancer tissues. Data from recent studies, however, suggest that most pro-tumor cells do not develop into tumors but remain dormant within or are prophylactically eliminated from tissues unless bestowed with additional driver mutations. Drosophila melanogaster has provided very efficient model systems, such as imaginal discs and ovarian follicular epithelia, to study the initial stage of tumorigenesis. This review will focus on the behaviors of emerging pro-tumor cells surrounded by normal cells and situations where they initiate tumor development.


Tumorigenesis Tumor hotspot Cell competition Epithelial tissues 



I thank K. Kozawa, C. Sabusap and J. Vaughen for critical reading and corrections of the manuscript. This work was supported by grants from JSPS KAKENHI Grant Number 17H05626 and 18KK0234 to Y.T.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Molecular Oncology, Institute for Genetic MedicineHokkaido UniversitySapporoJapan

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