18F-Fluoride Imaging: Atlas of Interesting Images (Images with Specific Teaching Points, Tracer, Technique, and Pitfalls)

  • Guofan XuEmail author
Part of the Clinicians’ Guides to Radionuclide Hybrid Imaging book series (CGRHI)


Uptake of 18F-NaF is not tumor specific, and nonmalignant entities can demonstrate radiotracer uptake, including arthritis, trauma, and bone processes such as fibrous dysplasia and Paget disease. The degree of radiotracer uptake cannot be used to differentiate benign from malignant lesions. Many benign bone lesions, including osteophytes and degenerative endplate changes, will show increased 18F-NaF uptake [1].


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    Segall G, et al. SNM practice guideline for sodium 18F-Fluride PET/CT bone scan 1.0. J Nucl Med. 2010;51(11):1813–20.CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Nuclear MedicineUniversity of Texas MD Anderson Cancer CenterHoustonUSA

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