Advertisement

18F-Fluoride Imaging: Normal Variants and Artifacts

  • Guofan XuEmail author
Chapter
Part of the Clinicians’ Guides to Radionuclide Hybrid Imaging book series (CGRHI)

Abstract

Sodium fluoride labeled with fluorine 18 (sodium fluoride F18 [18F-NaF]) is a bone seeking positron-emitting radiopharmaceutical tracer. 18F-NaF PET/CT provides great sensitivity and specificity in the detection of bone metastases. Uptake of 18F sodium fluoride reflects blood flow and bony remodeling. When combining with the CT component of the PET/CT, it allows better morphologic characterization of the functional findings and achieves more accurate differentiation with improved specificity.

References

  1. 1.
    Bastawrous S, et al. Newer PET application with an old tracer: role of 18F-NaF skeletal PET/CT in oncologic practice. RadioGraphics. 2014;34:1295–316.CrossRefGoogle Scholar
  2. 2.
    Sarikaya I, et al. Normal bone and soft tissue distribution of fluorine-18 sodium fluoride and artifacts on 18F NaF PET/CT bone scan: a pictorial review. Nucl Med Commun. 2017;38:810–9.CrossRefGoogle Scholar
  3. 3.
    Simpson CD, et al. FDG PET/CT: artifacts and pitfalls. Contemp Diagn Radiol. 2017;40(5):1.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Nuclear MedicineUniversity of Texas MD Anderson Cancer CenterHoustonUSA

Personalised recommendations