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18F-Sodium Fluoride Positron Emission Tomography in Cardiac Disease

  • Marwa DaghemEmail author
  • David E. Newby
Chapter
Part of the Clinicians’ Guides to Radionuclide Hybrid Imaging book series (CGRHI)

Abstract

Despite the recent advances, cardiovascular disease remains the leading cause of death worldwide. There is a need to improve targeting of existing novel diagnostic investigations. In the last few years, we have seen a rise in the availability of dedicated combined cardiac positron emission tomography scanners which combine molecular information from positron emission tomography with the fine anatomic detail provided by computed tomography or magnetic resonance imaging, which has in turn triggered a growing interest in the development of novel tracers providing new insight into biological disease processes. 18F-Sodium fluoride is a marker of active inflammation and calcification, and has shown promise as a novel radiotracer in cardiac imaging, having been applied in the assessment of a range of cardiac pathologies including atherosclerosis, valvular disease and cardiomyopathy.

Notes

Acknowledgements

MD and DEN are supported by the British Heart Foundation (CH/09/002, RE/18/5/34216) and a Wellcome Trust Senior Investigator Award (WT103782AIA).

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.British Heart Foundation/University of Edinburgh University Centre for Cardiovascular Science, University of EdinburghEdinburghUK

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