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Current Status of Stem Cell Transplantation for Autoimmune Diseases

  • Ngoc Bich Vu
  • Phuc Van PhamEmail author
Chapter
Part of the Stem Cells in Clinical Applications book series (SCCA)

Abstract

Autoimmune diseases (ADs) are common conditions of human health. These diseases can significantly reduce the patients’ quality of life. Although most autoimmune diseases can be controlled by certain immunosuppressive drugs, after long-term treatment, the therapeutic efficacy of these drugs can be significantly decreased while side effects may be increased. Recent reports have shown that stem cell therapy could improve the symptoms of ADs. Both hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) have been evaluated for the treatment of ADs in both animal models and clinical trials. While HSC transplantation (HSCT) can replace the immune system via autologous HSCT or allogeneic HSCT, MSC transplantation (MSCT) can improve ADs by other mechanisms which modulate the host’s immune system to repair the injured tissues via secreted factors. This chapter reviews and highlights recent therapeutic approaches and, particularly, the efficacy of stem cell therapy in AD treatment.

Keywords

Autoimmune disease Hematopoietic stem cells Mesenchymal stem cells stem cell therapy 

Abbreviations

AD

Autoimmune disease

ADSC

Adipose-derived stem cell

BM

Bone marrow

BUN

Blood urea nitrogen

CD

Crohn’s disease

CDAI

Crohn’s Disease Activity Index

CYC

Cyclophosphamide

G-CSF

Granulocyte-colony stimulating factor

GvHD

Graft-versus-host disease

HAQ

Health Assessment Questionnaire

HSC

Hematopoietic stem cell

HSCT

Hematopoietic stem cell transplantation

IL

Interleukin

IP

Intraperitoneal injection

IV

Intravenous infusion

mRSS

Modified Rodnan skin score

MS

Multiple sclerosis

MSC

Mesenchymal stem cell

MSCT

Mesenchymal stem cell transplantation

RA

Rheumatoid arthritis

SC

Stem cells

SLE

Systemic lupus erythematosus

SLEDAI

SLE disease activity index

SSc

Systemic sclerosis

SVF

Stromal vascular fraction

Th

T helper

Treg

Regulatory T cells

UC

Umbilical cord

Notes

Acknowledgment

This research was funded and supported by Fostering Innovation through Research, Science and Technology (FIRST), Viet Nam via project 15/FIRST/2a/SCI.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Stem Cell InstituteUniversity of Science, VNU-HCMHo Chi Minh CityVietnam
  2. 2.Laboratory of Stem Cell Research and ApplicationUniversity of Science, VNU-HCMHo Chi Minh CityVietnam

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