Prevention Strategies for Brain Metastasis

  • Riccardo SoffiettiEmail author
  • Alessia Pellerino
  • Roberta Rudà


This chapter summarizes the state of art of the past and ongoing efforts in the setting of prevention of brain metastases. PCI has a definite role in the prevention of relapses in the brain of patients with SCLC, in particular for those who completely responded to chemotherapy and radiotherapy. Conversely, PCI is able to reduce the incidence of brain metastasis but does not improve overall survival in NSCLC.

The new frontier of prevention is represented by the use of molecular agents with activity on macrometastases, but an efficacy on micrometastases as well needs to be investigated in adequately designed prevention trials.


PCI SCLC NSCLC Breast cancer Targeted agents 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Riccardo Soffietti
    • 1
    Email author
  • Alessia Pellerino
    • 1
  • Roberta Rudà
    • 1
  1. 1.Department of Neuro-OncologyUniversity and City of Health and Science Hospital TurinItaly

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