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Parvovirus-Related Arthritis

  • Martin Brom
  • Carlos Edgardo Perandones
Chapter

Abstract

Parvovirus B19 is a small virus with worldwide distribution and high infectivity rates, that affects mainly school-aged children, but previously non-infected adults are also susceptible. After infection, patients develop life-lasting neutralizing antibodies.

Infected patients may present with a myriad of symptoms, ranging between an asymptomatic state and flu-like disease to several manifestations of diverse severity, including fetal complications.

The most frequent manifestation of the disease in children is erythema infectiosum (fifth disease), while adults, especially woman, usually present with arthritis. Nevertheless, there is controversy on a possible role of Parvovirus B19 as a trigger for rheumatic diseases such as rheumatoid arthritis, lupus, vasculitis, and myositis, among others.

Keywords

Parvovirus B19, Human (D016732) Erythema Infectiosum (D016731) Arthritis, Infectious (D001170) Anemia, Aplastic (D000741) Red-Cell Aplasia, Pure (D012010) Hepatitis, Viral, Human (D006525) Myocarditis (D009205) Hydrops Fetalis (D015160) Arthritis, Rheumatoid (D001172) Arthritis, Juvenile (D001171) Encephalitis, Viral (D018792) Lupus Erythematosus, Systemic (D008180) Vasculitis (D014657) RS3PE Remitting Seronegative Symmetrical Synovitis with Pitting Edema 

Abbreviations

ACPA

Anti-citrullinated protein Antibodies

CFS

Chronic Fatigue Syndrome

CNS

Central Nervous System

CRP

C Reactive Protein

CSF

Cerebrospinal Fluid

EI

Erythema Infectiosum

ESR

Erythrocyte Sedimentation Rate

FM

Fibromyalgia

HBoV

Human Bocavirus 1 to 4

HLA

Human Leukocitary Antigen

INF-γ

Interferon γ

IL

Interleukin

IUT

Intrauterine Transfusion

JIA

Juvenile Idiopathic Arthritis

kD

Kilo Dalton

NIHF

Non-Immune Hydrops Fetalis

OA

Osteoarthritis

ORF

Open Reading Frame

PCR

Polymerase Chain Reaction

PPGSS

Papular Purpuric Gloves and Socks Syndrome

PRCA

Pure Red Cell Aplasia

PV-B19

Parvovirus B19

RA

Rheumatoid Arthritis

SLE

Systemic Lupus Erythematosus

sPLA2

Secreted Phospholipase A2

STAT3

Signal Transducer and Activator of Transcription 3

TAC

Transient Aplastic Crisis

TGF-β

Tissular Grow Factor β

TNF-α

Tumor Necrosis Factor α

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Martin Brom
    • 1
    • 2
  • Carlos Edgardo Perandones
    • 1
    • 3
  1. 1.Fundación FavaloroBuenos AiresArgentina
  2. 2.Hospital Italiano de Buenos AiresBuenos AiresArgentina
  3. 3.FLENI (Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia)Buenos AiresArgentina

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