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Selected Golgi-Localized Proteins and Carcinogenesis: What Do We Know?

  • Piotr Donizy
  • Jakub Marczuk
Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 67)

Abstract

The role of the Golgi apparatus in carcinogenesis still remains unclear. A number of structural and functional cis-, medial-, and trans-Golgi proteins as well as a complexity of metabolic pathways which they mediate may indicate a central role of the Golgi apparatus in the development and progression of cancer. Pleiotropy of cellular function of the Golgi apparatus makes it a “metabolic heart” or a relay station of a cell, which combines multiple signaling pathways involved in carcinogenesis. Therefore, any damage to or structural abnormality of the Golgi apparatus, causing its fragmentation and/or biochemical dysregulation, results in an up- or downregulation of signaling pathways and may in turn promote tumor progression, as well as local nodal and distant metastases. Three alternative or parallel models of spatial and functional Golgi organization within tumor cells were proposed: (1) compacted Golgi structure, (2) normal Golgi structure with its increased activity, and (3) the Golgi fragmentation with ministacks formation. Regardless of the assumed model, the increased activity of oncogenesis initiators and promoters with inhibition of suppressor proteins results in an increased cell motility and migration, increased angiogenesis, significantly activated trafficking kinetics, proliferation, EMT induction, decreased susceptibility to apoptosis-inducing factors, and modulating immune response to tumor cell antigens. Eventually, this will lead to the increased metastatic potential of cancer cells and an increased risk of lymph node and distant metastases. This chapter provided an overview of the current state of knowledge of selected Golgi proteins, their role in cytophysiology as well as potential involvement in tumorigenesis.

Notes

Acknowledgments

The authors thank Prof. Marzena Podhorska-Okołów and Dr. Katarzyna Haczkiewicz (Department of Human Morphology and Embryology, Wroclaw Medical University) for preparing the electron microphotographs and Ms. Agnieszka Janczak for her editorial support.

Source of Funding

A statutory subsidy by the Polish Ministry of Science and Higher Education as part of grant ST.B130.18.030 (record numbers in the Simple system).

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Piotr Donizy
    • 1
    • 2
  • Jakub Marczuk
    • 1
  1. 1.Department of Pathomorphology and Oncological CytologyWroclaw Medical UniversityWroclawPoland
  2. 2.Jan Mikulicz-Radecki University Teaching HospitalWroclawPoland

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