p53-Hsp90 Axis in Human Cancer
The heat shock protein 90 (Hsp90) is a ubiquitous molecular chaperone that is abundantly expressed in cancer cells and plays a pivotal role in correct folding and functions of a variety of oncogenic clients. Hsp90 is up-regulated in response to cellular stresses that cancer cells encounter, such as heat, hypoxia and nutrient deprivation, conditions commonly associated with the tumor microenvironment. P53 is the tumor suppressor gene that is mutated in nearly 50% of all human cancers. When mutated p53 not only lose its tumor suppressive function but also gain novel oncogenic activities via gain-of-function mechanisms leading to increased genomic instability, chemoresistance, and metastasis, which promote tumor progression. In contrast to wild-type p53, mutant p53 is protected from degradation via interaction with Hsp90 leading to marked stabilization of mutant p53 protein in cancer cells. Recent in vivo studies unequivocally have proven that the stabilization of mutant p53 is crucial pre-requisite for its oncogenic functions. The pharmacological targeting the pathways involved in the stabilization of mutant p53, in particular, the Hsp90 chaperone complex, recently attracted a lot of attention as a promising therapeutic approach to treat mutant p53 harboring cancers.
KeywordsCancer Gain-of-function Heat shock protein Hsp90 Loss of heterozygosity p53
heat shock factor 1
heat shock protein
loss of heterozygosity
mouse double-minute 2
receptor tyrosine kinases
suberoylanilide hydroxamic acid
This work was supported by the Department of Defense grant W81XWH-16-1-0448 (BC151569) and the Carol Baldwin Breast Cancer Research Fund to N. Marchenko.
- Shepherd FA, Lacas B, Le Teuff G et al (2017) Pooled analysis of the prognostic and predictive effects of TP53 comutation status combined with KRAS or EGFR mutation in early-stage resected non-small-cell lung cancer in four trials of adjuvant chemotherapy. J Clin Oncol 35:2018–2027PubMedPubMedCentralCrossRefGoogle Scholar
- Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM (1994) Inhibition of heat shock protein Hsp90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci USA 91:8324–8328PubMedCrossRefPubMedCentralGoogle Scholar