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Role of Heat Shock Protein 90 in Mammary Tumorigenesis

  • B. V. Sunil Kumar
  • Priya K. Gopal
  • Ramneek Verma
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 19)

Abstract

Heat shock proteins (HSP) are the proteins with a wide range of functions. They protect the cells from various stressors including heat stress and also act as chaperones thereby aiding in protein folding and maintenance of cellular homeostasis. Various members of HSP family have been associated with cancers. HSP90 is one such member which promotes protein folding and has an important role in breast cancer progression. Reports indicate that mammary tumor cells constitutively secrete HSP90 in order to facilitate tumor invasion and metastasis. Further, neutralisation of extracellular HSP90 or inhibition of its secretion or interruption of its signalling has been found to block cancer invasion. The recent findings that various isoforms of HSP90 are upregulated in breast neoplasia and breast cancer/mammary tumor subjects have elevated serum HSP90 levels suggest an important role of this chaperone in malignant transformation of mammary glands. This chapter briefly reviews recent advances in our understanding of the role of HSP90 in mammary gland tumorigenesis.

Keywords

Diagnosis Expression HSP90 HSP90 inhibitors Mammary gland Mammary tumor 

Abbreviations

AKT

Serine-threonine protein kinase

Bcl2

B-cell lymphoma gene 2

Bcl-XL

bcl-2-like 1

Cdk5

Cyclin-dependent kinase-5

Chk

Checkpoint kinase

CSC

Cancer stem cells

Dsh

Phosphoprotein Dishevelled

EGFR2/HER2

Epidermal growth factor receptor-2

FLT3

fms-like tyrosine kinase 3

GRP94

Endoplasmic reticulum Hsp90 homolog

GSK3β

Glycogen synthase kinase 3- beta

HIF-1α

Hypoxia-inducible factor 1-alpha

hsf1

Heat shock transcription factor 1

HSP

Heat shock proteins

IAP

Inhibitor of apoptosis protein

ILK

Integrin-linked kinase

MAPK1

Mitogen-activated protein kinase

MIF

Macrophage migration inhibitory factor

MMP

Matrix metalloproteinases

mTOR

Mammalian target of rapamycin

NFκB

Nuclear factor κ B

PKCα/PKCβ

Protein kinase C-alpha/beta

PTK2

Protein tyrosine kinase 2

Raf

Rapidly accelerated fibrosarcoma

SFRP1

Secreted frizzled related protein

SRC

Steroid receptor co-activator

Src

v-src sarcoma (Schmidt–Ruppin A-2) viral oncogene homolog (avian)

STAT

Signal Transducers and Activators of Transcription

TNBC

Triple negative breast cancer

TRAP

TNF-related activation protein

WNT

Wingless type MMTV integration site family member 1

Notes

Acknowledgements

the authors acknowledge Department of Biotechnology, Ministry of Science and Technology (Grant ID: BT/PR6434/GBD/27/414/2012) for carrying out research on diagnostic implication of Hsp90 on mammary tumors.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • B. V. Sunil Kumar
    • 1
  • Priya K. Gopal
    • 2
    • 3
  • Ramneek Verma
    • 1
  1. 1.Department of Microbial and Environmental Biotechnology, School of Animal BiotechnologyGuru Angad Dev Veterinary and Animal Sciences UniversityLudhianaIndia
  2. 2.Department of Botany, Centre of Advanced StudiesUniversity of CalcuttaKolkataIndia
  3. 3.Department of MicrobiologyMuralidhar Girls’ CollegeKolkataIndia

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