Therapeutic Potential of Heat Shock Protein 90 Inhibitors in Colorectal Cancer

  • Reyhaneh Moradi-Marjaneh
  • Seyed Mahdi Hassanian
  • Gordon A. Ferns
  • Amir AvanEmail author
  • Majid KhazaeiEmail author
Part of the Heat Shock Proteins book series (HESP, volume 19)


Colorectal cancer (CRC) is one of the most common causes of cancer- related death globally. Despite recent advances in diagnosis and treatment, CRC remains one of the leading cause mortality, with 5 years survival rate of approximately 60%. Hence, there is an urgent need for new therapeutic approaches. A large number of Hsp90 client proteins have importance in the stability and function of crucial oncogenic proteins and play critical roles in the development of CRC. Hence, Hsp90 inhibitors may have therapeutic benefits in the treatment of CRC, and they are currently in clinical trials for various malignancies. In this chapter, we have reviewed the potential role of Hsp90 in the pathogenesis of CRC, and have summarized recent preclinical and clinical studies of Hsp90 inhibitors as a potential therapeutic in CRC.


Cancer Clinical Colorectal Hsp90 inhibitors Treatment 



15-hydroxyprostaglandin dehydrogenase


Protein kinase B


Bcl-2 interacting mediator of cell death


Cyclin-dependent kinase 2




Cell-extracellular matrix


Extracellular signal–regulated kinases




Fibroblast growth factor receptor


Human epidermal growth factor receptor 2


IκB kinase


Lipoprotein receptor-related protein 1


Matrix metalloproteinase 9


Nuclear factor kappa-light-chain-enhancer of activated B cells


Non-neoplastic mucosa


Positron emission tomography


Prostaglandin E2


Phosphoinositide 3 – kinase


Protein kinase C


Retinoic acid-inducible gene I


Serine/threonine kinase 33


Transcription factor 12


Tumor necrosis factor associated protein


Tyrosine kinase 2



This research was partly supported by grants awarded by the Mashhad University of Medical Sciences, grant No. 940908 and National Institute for Medical research Development, grant No. 958349.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Reyhaneh Moradi-Marjaneh
    • 1
  • Seyed Mahdi Hassanian
    • 2
    • 3
  • Gordon A. Ferns
    • 4
  • Amir Avan
    • 2
    • 5
    • 6
    Email author
  • Majid Khazaei
    • 2
    • 7
    Email author
  1. 1.Torbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran
  2. 2.Metabolic Syndrome Research CenterMashhad University of Medical SciencesMashhadIran
  3. 3.Department of Medical Biochemistry, Faculty of MedicineMashhad University of Medical SciencesMashhadIran
  4. 4.Division of Medical EducationBrighton & Sussex Medical SchoolBrightonUK
  5. 5.Cancer Research CenterMashhad University of Medical SciencesMashhadIran
  6. 6.Department of Modern Sciences and Technologies, Faculty of MedicineMashhad University of Medical SciencesMashhadIran
  7. 7.Department of Physiology, Faculty of MedicineMashhad University of Medical SciencesMashhadIran

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