Hsp90: Is There an Unknown Role in Pain Neurobiology

  • João Dias-Ferreira
  • Fani L. Moreira NetoEmail author
Part of the Heat Shock Proteins book series (HESP, volume 19)


Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that is essential in protein homeostasis and normal cell growth and survival, assisting protein folding, protein degradation and being highly recruited in cellular stress conditions. The implication of Hsp90 in several pathological conditions is being increasingly recognized, particularly in cancer, an area of intense research on the use of different Hsp90 inhibitors as a possible therapeutic approach, as well as on the associated mechanisms of action. There is also strong indication that the Hsp90 chaperone is involved in inflammation and neuroinflammation, and neurodegeneration events. Here we summarize some scientific evidence suggesting that Hsp90, and possibly its mitochondrial-compartimentalized homologue Tumour Necrosis Factor Receptor-Associated Protein 1 (TRAP-1), participate also in pain processing mechanisms.


Hsp90 Mitochondrial homologue Neuroinflammation Neuropathic pain Oxidative stress Pain neurobiology 







Activating transcription factor 3


Chronic constriction injury


Calcitonin-gene-related peptide


Carboxyl terminus of Hsp70-interacting protein


Cyclophilin D


Danger-associated molecular pattern


Extracellular signal-regulated kinases


Glial fibrillary acidic protein


Gyrase, Hsp90, Histidine Kinase and MutL


Heat shock element


Heat shock factor 1


Heat shock proteins


Heat shock protein 70


Heat shock protein 90


Inhibitor of κB (IκB) Kinase complex


Interleukin 10


Interleukin 1 beta


Interleukin 6


Inhibitor of κB


JAK/Signal Transducer and Activator of Transcription (STATs)


c-Jun N-terminal kinase


Mitogen-activated protein kinases


Mu-opioid receptor


Mitochondrial permeability transition pore


Nicotinamide adenine dinucleotide phosphate


Nuclear factor-kappa B


Nitric oxide


NO synthases


Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases


PTEN-induced Putative Kinase 1


Pattern recognition receptors


Receptor interacting kinase


Reactive nitrogen species


Reactive oxygen species


Small interference RNA


Substance P


Signal transducer and activator of transcription


TGF-β-activated kinase-1/Inhibitor of κB (IκB) Kinase complex


Toll-like-receptor 2


Toll like-receptor 4


Tumour necrosis factor alpha


Tumour necrosis factor receptor-associated protein 1




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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • João Dias-Ferreira
    • 1
    • 2
    • 3
  • Fani L. Moreira Neto
    • 1
    • 2
    • 3
    Email author
  1. 1.i3S – Instituto de Investigação e Inovação em SaúdeUniversidade do PortoPortoPortugal
  2. 2.IBMC – Instituto de Biologia Molecular e CelularUniversidade do PortoPortoPortugal
  3. 3.Departamento de Biomedicina – Unidade de Biologia Experimental, Faculdade de MedicinaUniversidade do PortoPortoPortugal

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