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Heat Shock Protein 90 in Severe Trauma

  • Yan Zhao
  • Yuan-Guo ZhouEmail author
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 19)

Abstract

Trauma is an important health problem in modern society. Its serious consequences, such as sepsis and multiple organ dysfunction, are the leading causes of high morbidity and mortality. The heat shock proteins (HSP) increase rapidly under a wide variety of stressful conditions to protect cell from damage. Overexpression of HSP is associated with apoptosis inhibition, inflammatory response and immunomodulation in severe trauma. Therefore, the changes in expression levels of various heat shock proteins or the differences in genetic background will affect the processes and medical outcomes of patients or animal models of diseases. Most importantly, HSP play differential and complex roles in the regulation of inflammation and immunity at different pathological stages and locations after severe trauma. In addition to the traditional therapeutic methods, strategies by the control of HSP expression and consideration of individual genetic background will pave the way for the better treatment and prediction of serious complications caused by severe trauma. In this chapter, the recent progresses of HSP in severe trauma and its complications and the possibilities of HSP as therapeutic targets will be discussed.

Keywords

Gene polymorphism Multiple organ dysfunction syndrome Sepsis Severe trauma Shock 

Abbreviations

DIC

Disseminated intravascular coagulation

HSP

Heat shock proteins

IL

Interleukin

MODS

Multiple organ dysfunction syndrome

Notes

Acknowledgements

The authors thank the State Key Laboratory of Trauma, Burn and Combined Injury. This work was supported in part by the National Natural Science Foundation of China [Grant 30470988].

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Molecular Biology Center, The State Key Laboratory of Trauma, Burn and Combined Injury, Research Institute of Surgery and Daping HospitalThird Military Medical UniversityChongqingChina

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