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Theranostic Implications of Heat Shock Proteins in Idiopathic Pulmonary Fibrosis

  • Ganapasam SudhandiranEmail author
  • Divya Thomas
  • Vadivel Dineshbabu
  • Soumya Krishnan
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 19)

Abstract

Heat shock proteins, also known as ‘stress proteins’ are large family of chaperones that are involved in the proper formation, maturation and maintenance of variety of proteins to promote cell survival under stress condition. Normal chaperone machinery is essential for the endogenous adaptation of several tissues in stress environment; however, altered chaperone function has been strongly associated with the molecular orchestration in the progression of several diseases. Therefore, inhibitors of molecular chaperones are emerging as attractive drug targets against various diseases. Idiopathic pulmonary fibrosis is a grave disease whose pathogenic factors remain unknown. Multiple mechanisms including TGFβ/Smad regulated epithelial mesenchymal transition and aberrant cell death pattern contribute to this disease. Recently, growing body of evidences demonstrate the involvement of large and small heat shock proteins contributing to this disease. The knowledge about the pathophysiological role of heat shock proteins has been well updated in cancers; however, its role in the initiation and progression of fibrosis is poorly addressed. Since the therapeutic options for pulmonary fibrosis are very much limited, it is noteworthy to discuss the important theranostic applications of heat shock proteins in pulmonary fibrosis which is becoming a blistering field in fibrosis research.

Keywords

Apoptosis Heat shock proteins Idiopathic pulmonary fibrosis Molecular chaperones Transforming growth factor beta 

Abbreviations

AEC

Alveolar epithelial cells

ECM

Extra cellular matrix

EMT

Epithelial to mesenchymal transition

Hsp

Heat shock proteins

IPF

Idiopathic pulmonary fibrosis

MAPK

Mitogen activated protein kinase

MMP

Matrix metalloproteases

ROS

Reactive oxygen species

TGFβ

Transforming growth factor beta

Notes

Acknowledgements

The authors thank Indian Council of Medical Research (ICMR), New Delhi, Govt. of India for a major research grant (52/21/08/BMS/) in Pulmonary fibrosis.

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ganapasam Sudhandiran
    • 1
    Email author
  • Divya Thomas
    • 1
  • Vadivel Dineshbabu
    • 1
  • Soumya Krishnan
    • 1
  1. 1.Cell Biology Laboratory, Department of BiochemistryUniversity of MadrasChennaiIndia

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