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Exosomal Hsp60: A Tumor Biomarker?

  • Stefano Fais
  • Mariantonia Logozzi
  • Giusi Alberti
  • Claudia CampanellaEmail author
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 18)

Abstract

Exosomes (EXs) are extracellular vesicles containing proteins, DNA, mRNA, non-coding RNAs, such as miRNAs, and lipid. The EXs can be easily isolated from different biological fluids and their content is considered a potential biomarker in various diseases, such as cancer. EXs play an important role in intercellular communication, permitting cells to exchange proteins, lipids, and genetic material in normal and pathological conditions. New data have shown that tumor cells-derived EXs contribute to cancer progression through the modulation of tumor microenvironment. Heat shock proteins 60 kDa (Hsp60) is classically considered mitochondrial proteins with different biological roles. In recent years, many studies have focused on the extracellular roles played by Hsp60 that appear to be involved in cancer development and immune system stimulation. Hsp60 is localized on the surface of EXs, secreted by cells and could be a key player in intercellular cross-talk during the course of different diseases. Therefore, exosomal Hsp60 has a great potential for clinical applications, including its use as biomarker for diagnostics, assessing prognosis, and monitoring disease progression and response to treatment, particularly in cancer.

Keywords

Exosomes Heat shock proteins Hsp Hsp60 Tumor biomarker 

Abbreviations

ESCRT

endosomal sorting complex

EVs

extracellular vesicles

EXs

exosomes

Hsp

heat shock proteins

Hsp60

heat shock protein 60 kDa

ILVs

intraluminal vesicles

MVBs

multivesicular bodies

Notes

Acknowledgements

C.C. and G.A. C.C.B. were partially supported by UniPA.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Stefano Fais
    • 1
    • 2
  • Mariantonia Logozzi
    • 1
  • Giusi Alberti
    • 3
  • Claudia Campanella
    • 2
    • 3
    Email author
  1. 1.Department of Therapeutic Research and Medicines EvaluationNational Institute of HealthRomeItaly
  2. 2.Euro-Mediterranean Institute of Science and Technology (IEMEST)PalermoItaly
  3. 3.Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human AnatomyUniversity of PalermoPalermoItaly

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