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Evaluation of Heat Shock Protein 60 (HSP60) Chaperonin in Oncology

  • İsmail Ağababaoğlu
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 18)

Abstract

Heat shock proteins (Hsp) are a group of chaperonin that are increased production at cellular level in cellular stress situations. These stress include such as heat, infection, inflammation, many toxins such as ethanol, arsenic, some metals, ultraviolet light, some oncogenes. Under physiological conditions, Hsp helps the newly produced proteins in the cell in folding correctly. They provide stabilization of the mitochondria as a mechanism that prevents the cell from apoptosis. They function by interacting with proteins called chaperonin in the cell cycle and stabilization of mitochondria. And it protects the cell from apoptosis and directs it to the process of carcinogenesis. Therefore, it has great potential in cancer studies in many stages. Thus, our chapter aims to briefly evaluate up to date knowledge for Hsp in oncological field.

Keywords

Biomarker Cancer vaccines Chaperonin Carcinogenesis Heat shock protein 60 Target therapy 

Abbreviations

2D gel

Two-dimensional gel

5-FU

5- fluorouracil

17AAG

17-Allylamino-Demethoxygeldanamycin

ATPase

adenosine triphosphate

CA-19-9

cancer Antigen 19-9

CD8

cytotoxic T cells surface antigen

CEA

carcinoembryonic antigen

c-MYC

myelocytomatosis oncogene

Cyp-D

peptidylprolyl isomerase D (cyclophilin D)

E-Box

enhancer box

ELISA

Enzyme-linked immunosorbent assay

HCV

hepatitis C virus

HSP

heat shock protein

kDa

kilodaltons

MALDI-TOF

matrix assisted laser desorption ionization time of flight mass spectrometry

Mrna

messenger ribonucleic acid

PSA

prostate specific antigen

PCR

polymerase chain reaction

SW80

human colorectal cancer cell line

TNF-Alpha

tumor necrosis factor-alpha

Notes

Acknowledgments

I wish to thank Safiye Aktaş, Cahit Koçak and Efe Özgür Serinan for contributing many ideas that improved the chapter.

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • İsmail Ağababaoğlu
    • 1
  1. 1.Department of Thoracic SurgeryYıldırım Beyazıt University Yenimahalle Research HospitalAnkaraTurkey

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