Inflammatory Myopathies

  • Eleni TiniakouEmail author
  • Michael Wu


Due to the discovery of novel antibodies and their close association to distinct clinical phenotypes, as well as the description of distinct histological patterns, rheumatologists are now able to categorize inflammatory myopathies into four main subtypes. While these subtypes often share the characteristic symptoms of muscle weakness and skeletal muscle inflammation, there are important differences based on epidemiology, clinical presentation, extramuscular manifestations, muscle pathology, and treatment. This chapter will help rheumatologists recognize these differences so that tools such as MRI, EMG/NCS, and biopsy can be used accurately to diagnose these inflammatory myopathies from other etiologies of muscle weakness. Furthermore, knowing these unique antibody associations to phenotype will help guide anticipatory malignancy testing, extramuscular manifestation screening, and treatment.


Idiopathic inflammatory myopathies Dermatomyositis Immune-mediated necrotizing myopathy Inclusion body myositis Polymyositis Antisynthetase syndrome Amyopathic Autoantibodies Interstitial lung disease Malignancy 

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Division of Rheumatology, Department of MedicineJohns Hopkins University, School of MedicineBaltimoreUSA

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