Nutritional epigenetics is a sub-discipline of nutrigenomics and describes how dietary compounds affect our epigenome. Chromatin modifiers use intermediary metabolites, such as acetyl-CoA, α-ketoglutarate, NAD+, FAD, ATP or SAM, as co-substrates and/or co-factors. In this way, chromatin modifiers act as sensors for the nutritional status of our tissues and cell types leaving respective marks on their epigenome. The thrifty phenotype is a concept of epigenetic programing of metabolic tissues during pre-natal development. Its principles apply also in adult life and may explain the missing heritability of the susceptibility for complex metabolic diseases, such as type 2 diabetes.
KeywordsNutrigenomics Energy metabolism Acetyl-CoA NAD+ SAM Folate Thrifty phenotype Type 2 diabetes Personalized nutrition
- Carlberg C, Ulven SM, Molnár F (2016) Nutrigenomics Springer Textbook ISBN: 978-3-319-30413-7Google Scholar