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Introduction

  • Carsten Carlberg
  • Ferdinand Molnár
Chapter

Abstract

Chromatin is the physical representation of epigenetics. The degree of chromatin compaction is inversely correlated with gene expression. The epigenome responds to intra- and extra-cellular signals via changes in DNA methylation and histone modifications. Accordingly, the epigenetic landscape visualizes epigenomic changes during cellular differentiation, tumorigenesis and other cellular perturbations. Thus, the proper action of the epigenome has a major impact on our health and disease.

Keywords

Epigenetics Chromatin Euchromatin Heterochromatin Human genome Gene Central dogma of molecular biology Epigenome Epigenetic landscape Big Biology projects 

Further Reading

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Carsten Carlberg
    • 1
  • Ferdinand Molnár
    • 2
  1. 1.Institute of BiomedicineUniversity of Eastern FinlandKuopioFinland
  2. 2.Department of BiologyNazarbayev UniversityNur-SultanKazakhstan

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