Halo nevus, synonymously known as Sutton’s nevus or leukoderma acquisitum centrifugum, is a benign melanocytic nevus surrounded by a zone with loss of pigmentation. It mostly affects young individuals and the commonest sites are upper back, neck and abdomen. Host’s immunologic reactions consisting of inflammatory cytokines and cytotoxic CD8+ T cells are the culprits. Histopathologically, the nevus may be junctional, compound or dermal showing dense lymphocytic infiltrates in the dermis. The peripheral depigmented halo has little or no lymphocytic infiltrate. Mayerson’s nevus, cockade nevus and regressing melanoma with halo are the simulating entities which can be differentiated by morphology and histopathology. A young female presented with a black papule on left upper region of neck surrounded by an oval depigmented halo. Histopathology of central papule revealed nevomelanocytic proliferations and dense dermal lymphocytic infiltrates. The central nevus may partially or completely regress in years with or without repigmentation of halo. Halo nevus can be left or excised completely.
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Rados J, Pastar Z, Lipozencic J, Ilic I, Stulhofer Buzina D. Halophenomenon with regression of acquired melanocytic nevi: a case report. Acta Dermatovenerol Croat. 2009;17:139–43.PubMedGoogle Scholar
Aouthmany M, Weinstein M, Zirwas MJ, Brodell RT. The natural history of halo nevi: a retrospective case series. J Am Acad Dermatol. 2012;67:582–6.CrossRefGoogle Scholar
Moretti S, Spallanzani A, Pinzi C, Prignano F, Fabbri P. Fibrosis in regressing melanoma versus nonfibrosis in halo nevus upon melanocyte disappearance: could it be related to a different cytokine microenvironment? J Cutan Pathol. 2007;34:301–8.CrossRefGoogle Scholar
Akasu R, From L, Kahn HJ. Characterization of the mononuclear infiltrate involved in regression of halo nevi. J Cutan Pathol. 1994;21:302–11.CrossRefGoogle Scholar
Wollina U. Nevi presenting a halo: Sutton nevus, Meyerson nevus, and Wollina-Schaarschmidt halo-like dermatosis. Our Dermatol Online. 2017;8(2):149–51.CrossRefGoogle Scholar
Mehregan AH, King JR. Multiple target-like pigmented nevi. Arch Dermatol. 1972;105:129–30.CrossRefGoogle Scholar
Naveh HP, Rao UN, Butterfield LH. Melanoma-associated leukoderma—immunology in black and white? Pigment Cell Melanoma Res. 2013;26(6):796–804.CrossRefGoogle Scholar
Rubegni P, Nami N, Risulo M, Tataranno D, Fimiani M. Melanoma with halo. Clin Exp Dermatol. 2009;34:749–50.CrossRefGoogle Scholar