A Young Female with Generalized Mottled Pigmentation

  • Swetalina Pradhan
  • Kananbala Sahu
Part of the Clinical Cases in Dermatology book series (CLIDADE)


Dyschromatosis universalis hereditaria is an autosomal dominant condition with an onset in infancy or early childhood and is characterized by generalized mottled pigmentation. Palm, sole and oral mucosa too may be affected. The nails may be hyperpigmented and dystrophic with pterygium formation. The condition is benign and does not cause significant morbidity. However, it follows a progressive course. There is no effective treatment.


Mottled pigmentation Reticulate pigmentary disorders Dyschromatosis Dyschromatosis universalis hereditaria 


  1. 1.
    Urabe K, Hori Y. Dyschromatosis. Semin Cutan Med Surg. 1997;16:81–5.CrossRefGoogle Scholar
  2. 2.
    Suzuki N, Suzuki T, Inagaki K, Ito S, Kono M, Fukai K, et al. Mutation analysis of the ADAR1 gene in dyschromatosis symmetrica hereditaria and genetic differentiation from both dyschromatosis universalis hereditaria and acropigmentatio reticularis. J Invest Dermatol. 2005;124:1186–92.CrossRefGoogle Scholar
  3. 3.
    Bolognia JL. Disorders of hypopigmentation and hyperpigmentation. In: Harper J, Orange H, Prose N, editors. Textbook of pediatric dermatology. 2nd ed. Hoboken: Blackwell Science; 2000. p. 868–70.Google Scholar
  4. 4.
    Ramrath K, Stolz W. Disorders of melanin pigmentation. In: Burgdorf W, Plewig G, Wolff HH, Landthaler M, editors. Braun Falco’s dermatology. 3rd ed. New York: Springer; 2009. p. 772–4.Google Scholar
  5. 5.
    Tiwary AK, Mishra DK, Chaudhary SS. Amyloidosis cutis dyschromica: a rare dyschromic subtype of primary cutaneous amyloidosis. Pigment Int. 2016;3:33–6.CrossRefGoogle Scholar
  6. 6.
    Nogita T, Mitsuhashi Y, Takeo C, Tsuboi R. Removal of facial and labial lentigines in dyschromatosis universalis hereditaria with a Q-switched alexandrite laser. J Am Acad Dermatol. 2011;65:61–3.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Swetalina Pradhan
    • 1
  • Kananbala Sahu
    • 2
  1. 1.All India Institute of Medical SciencesPatnaIndia
  2. 2.All India Institute of Medical SciencesBhubaneswarIndia

Personalised recommendations