Heart – Coronary Vessels and Cardiomyocytes

  • Anderson José FerreiraEmail author
  • Carlos Henrique Castro
  • Robson Augusto Souza Santos


The renin-angiotensin system (RAS) is crucial for cardiovascular homeostasis. Its relevance is highlighted by the undiscussed role of the anti-hypertensive drugs that modulate this system used in the medical practice. Nowadays, the Angiotensin(Ang)-(1-7) peptide is recognized as a biologically active component of this system. This heptapeptide is formed mainly through the action of the angiotensin-converting enzyme 2 (ACE2) using Ang II as substrate. This reveals an important metabolic pathways since, at the same time, ACE2 degrades the vasoconstrictor peptide Ang II and generates Ang-(1-7), a vasodilator product. Additionally, it is well-established that the G protein-coupled receptor Mas is a functional ligand site for Ang-(1-7). Also, it is now clear that the RAS is composed by two different axes: ACE/Ang II/AT1 receptor and ACE2/Ang-(1-7)/Mas. Functionally, the ACE2/Ang-(1-7)/Mas arm is an endogenous counter-regulatory pathway within the RAS whose actions are opposite to the vasoconstrictor/proliferative axis of the RAS formed by ACE/Ang II/AT1 receptor. In this chapter, we will briefly discuss the main findings concerning the biological role of Ang-(1-7) and its receptor Mas focusing on coronary vessels and cardiomyocytes.


Angiotensin II Mas agonists Heart Cardiovascular function Antihypertensive drugs 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Anderson José Ferreira
    • 1
    Email author
  • Carlos Henrique Castro
    • 2
  • Robson Augusto Souza Santos
    • 3
    • 4
  1. 1.Department of MorphologyBiological Sciences Institute, Federal University of Minas GeraisBelo HorizonteBrazil
  2. 2.Department of Physiological SciencesBiological Sciences Institute, Federal University of GoiásGoiâniaBrazil
  3. 3.National Institute of Science and Technology in Nano Biopharmaceutics – Department of Physiology and BiophysicsBiological Sciences Institute, Federal University of Minas GeraisBelo HorizonteBrazil
  4. 4.Department of Physiology and PharmacologyBiological Sciences Institute, Federal University of Minas GeraisBelo HorizonteBrazil

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