Cyanide Poisoning—“I’m Mr. Blue…”

  • Jessica A. EverettEmail author
  • Colin G. Kaide
  • Hannah Hays


Cyanide is a very old and revered toxin, deviously appearing in plants, seeds/pits, and in almost every household item made of plastic, polyurethane, or some such derivative. It works by blocking what is likely the most efficient energy-producing mechanism that nature has created, the production of ATP via oxidative phosphorylation. Toxicity includes collapse of all oxygen-dependent systems including, most importantly, the central nervous system (CNS) and the cardiovascular system. The treatment is supportive care while trying to remove the cyanide from the electron transport chain and reverse its devastating effects!


Cyanide  House fire Hydroxocobalamin  Hyperlactatemia  Apricot pit  Anion-gap metabolic acidosis 


Disclosure Statement

  • Jessica A. Everett. Clarius. Not relevant to this publication

  • Colin Kaide. Callibra, Inc.-Discharge 123 medical software company. Medical Advisory Board Portola Pharmaceuticals. I have no relationship with a commercial company that has a direct financial interest in subject matter or materials discussed in article or with a company making a competing product.

  • Hannah Hays No conflicts


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Jessica A. Everett
    • 1
    Email author
  • Colin G. Kaide
    • 1
  • Hannah Hays
    • 2
    • 3
    • 4
  1. 1.Department of Emergency MedicineWexner Medical Center at The Ohio State UniversityColumbusUSA
  2. 2.Department of Emergency Medicine, Wexner Medical Center at The Ohio State UniversityColumbusUSA
  3. 3.Central Ohio Poison CenterColumbusUSA
  4. 4.Nationwide Children’s HospitalColumbusUSA

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