Pancreatic Neuroendocrine Tumors and Other Solid Tumors of Pancreas
This chapter reviews the key features that define pancreatic neuroendocrine neoplasia, acinar cell carcinoma, solid pseudopapillary neoplasm, and pancreatoblastoma on cytology specimens. These four tumors often share overlapping clinical and morphologic features and consequently must often be considered together within the same differential diagnosis. This large amount of potential morphologic overlap requires the use of ancillary immunohistochemical studies in most cases in order to arrive at accurate diagnoses. The ability to effectively diagnose these entities is critical as each diagnosis portends dramatically different prognoses and treatment. This chapter will review the key clinical, cytomorphologic, and immunohistochemical features required to effectively work through this challenging differential diagnosis.
KeywordsPancreatic neuroendocrine tumor Acinar cell carcinoma Solid pseudopapillary neoplasm Pancreatoblastoma Solid pancreatic tumors Endoscopic ultrasound guided fine needle aspiration
- 1.Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumors of the digestive system. Lyon: IARC; 2010.Google Scholar
- 2.Sigel CS. Advances in the cytologic diagnosis of gastroenteropancreatic. Cancer Cytopathol. 2018. Epub ahead of print. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/cncy.22073.
- 4.Odze RD, Goldblum JR. Surgical pathology of the GI tract, liver, biliary tract, and pancreas. Philadelphia: Saunders/Elsevier; 2015.Google Scholar
- 17.La Rosa S, Sessa F, Capella C. Acinar cell carcinoma of the pancreas: overview of clinicopathologic features and insights into the molecular pathology. Front Med (Lausanne). 2015;2(41). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469112/.
- 29.Bardales RH, Centeno B, Mallery JS, Lai R, Pochapin M, Guiter G, Stanley MW. Endoscopic ultrasound-guided fine-needle aspiration cytology diagnosis of solid-pseudopapillary tumor of the pancreas: a rare neoplasm of elusive origin but characteristic cytomorphologic features. Am J Clin Pathol. 2004;121(5):654–62.CrossRefGoogle Scholar