Pancreatic Neuroendocrine Tumors and Other Solid Tumors of Pancreas

  • Jacob SweeneyEmail author
  • Rema Rao
Part of the Essentials in Cytopathology book series (EICP, volume 28)


This chapter reviews the key features that define pancreatic neuroendocrine neoplasia, acinar cell carcinoma, solid pseudopapillary neoplasm, and pancreatoblastoma on cytology specimens. These four tumors often share overlapping clinical and morphologic features and consequently must often be considered together within the same differential diagnosis. This large amount of potential morphologic overlap requires the use of ancillary immunohistochemical studies in most cases in order to arrive at accurate diagnoses. The ability to effectively diagnose these entities is critical as each diagnosis portends dramatically different prognoses and treatment. This chapter will review the key clinical, cytomorphologic, and immunohistochemical features required to effectively work through this challenging differential diagnosis.


Pancreatic neuroendocrine tumor Acinar cell carcinoma Solid pseudopapillary neoplasm Pancreatoblastoma Solid pancreatic tumors Endoscopic ultrasound guided fine needle aspiration 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineWeill-Cornell Medicine, New York Presbyterian HospitalNew YorkUSA

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