Advertisement

Disposition and Fate of Toxicants

  • PK Gupta
Chapter

Abstract

This chapter deals with the study of absorption, distribution, metabolism/biotransformation, and excretion (ADME) of xenobiotics and the study of toxicokinetics of toxicants/xenobiotics in relation to time in animals. Toxicokinetics represents behavior of drugs in the system and extension of kinetic principles to the study of toxicology including applications ranging from the study of adverse drug effects to investigations on how disposition kinetics of exogenous chemicals are derived from either natural or environmental sources that govern their deleterious effects on animals and human beings.

Keywords

Absorption Disposition Biotransformation Metabolism Excretion Redistribution Toxicokinetics ADME Multiple choice questions 

Further Reading

  1. Beasley V (1999) Absorption, distribution, metabolism, and elimination: differences among species. In: Beasley V (ed) Veterinary toxicology. International Veterinary Information Service (www.ivis.org), Ithaca https://www.researchgate.net/publication/268347521_Absorption_Distribution_Metabolism_and_Elimination_Differences_Among_Species_9-Aug-1999
  2. Gupta PK (2010) Absorption, distribution, & excretion of xenobiotics. In: Gupta PK (ed) Modern toxicology: basis of organ and reproduction toxicity, vol 1, second reprint. PharmaMed Press, Hyderabad, pp 71–92Google Scholar
  3. Gupta PK (2016) Fundamental of toxicology: essential concept and applications. Elsevier/BSP, San Diego. (Chapters 8 and 9)Google Scholar
  4. Gupta PK (2018) Illustrative toxicology, 1st edn. Elsevier, San DiegoGoogle Scholar
  5. Lehman-McKeeman LD (2013) Absorption distribution and excretion of toxicants. In: Klaassen CD (ed) Casarett and Doull’s toxicology: the basic science of poisons, 8th edn, McGraw-Hill, pp 153–184Google Scholar
  6. Patkinson A, Ogilvie BW (2013) Biotransformation of xenobiotics. In: Klaassen CD (ed) Casarett and Doull’s toxicology: the basic science of poisons, 8th edn. McGraw-Hill, New York, pp 185–366Google Scholar
  7. Shen DD (2013) Toxicokinetics. In: Klaassen CD (ed) Casarett and Doull’s toxicology: the basic science of poisons, 8th edn. McGraw-Hill, New York, pp 367–390Google Scholar
  8. Timbrell JA (2009) Factors affecting toxic responses: disposition. In: Timbrell JA (ed) Principles of biochemical toxicology, 4th edn, Informa, New York, pp 35–74Google Scholar
  9. Van der Merwe D, Gehring R, Buur JL (2018) Toxicokinetics in veterinary toxicology. In: Gupta RC (ed) Veterinary toxicology: basic and clinical principles, 3rd edn. Academic Press/Elsevier, Amsterdam, pp 133–144CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • PK Gupta
    • 1
  1. 1.Toxicology Consulting Group, Academy of Sciences for Animal WelfareBareillyIndia

Personalised recommendations