Antimicrobial Stewardship in Immunocompromised Hosts

  • Wonhee So


Although an antimicrobial stewardship program (ASP) as a primary tool to combat global development of antimicrobial resistance has been widely accepted in the last decade, the key principles of ASP have not always been adopted in patients with significant immune defects. Multiple barriers exist for implementing ASP in this population: physician’s perceptions regarding the immunocompromised as sicker patients and fear of poor outcomes, a wide range of possible infectious etiologies with diagnostic uncertainty, complexity in making early diagnosis, impaired inflammatory responses, and difficulty in controlling the source of infections due to thrombocytopenia, and limited surgical interventions. However, ASP in the immunocompromised hosts is an important patient safety measure as development of multidrug-resistant (MDR) pathogens is an emerging problem. This chapter discusses strategies and the need for ASP in the immunocompromised host with cancer.


Antimicrobial stewardship program (ASP) Formulary Management Drug Interactions Early de-escalation in febrile neutropenic patients Antimicrobial Restriction Prospective audit and feedback Microbiological data Duration of therapy Antifungal stewardship Biomarkers Rapid Diagnostics Intravenous to oral 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Wonhee So
    • 1
  1. 1.San AntonioUSA

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