Interventions to Prevent Sperm DNA Damage Effects on Reproduction

  • Sandro C. EstevesEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1166)


Excessive oxidation and antioxidant imbalance resulting from several conditions may cause sperm DNA damage, which, in turn, affect male fertility, both natural and assisted. Sperm DNA damage transferred to the embryo might also affect the health of offspring. Several conditions associated with excessive oxidative stress are modifiable by the use of specific treatments, lifestyle changes, and averting exposure to environmental/occupational toxicants. Here, we discuss the strategies to reduce sperm DNA damage with a focus on clinical and surgical interventions.


Sperm DNA fragmentation Male infertility Semen analysis Assisted reproductive technology Varicocele Unexplained infertility Intrauterine insemination In vitro fertilization Intracytoplasmic sperm injection Recurrent pregnancy loss Testicular sperm Lifestyle modifications 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.ANDROFERT, Andrology and Human Reproduction Clinic, Referral Center for Male ReproductionCampinasBrazil
  2. 2.Department of Surgery (Division of Urology)University of Campinas (UNICAMP)CampinasBrazil
  3. 3.Faculty of HealthAarhus UniversityAarhusDenmark

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