Oxidative Damage to Sperm DNA: Attack and Defense
Due to its particular “silent” metabolic state, without transcription or translation, and a low level of cytosolic protective activities, mature sperm is a cellular type of aerobic organisms particularly at risk of oxidative damage. Despite the efforts of the male genital tract to treat this problem, a subcellular compartment of the sperm, the nucleus, and consequently, the paternal DNA cannot be effectively protected. There is an accumulation of evidence that oxidative damage to sperm DNA is quite common in male infertilities/subfertilities with potential harmful impacts on reproductive success, including the transgenerational inheritance of a paternal chromosomal lot carrying mutations.
KeywordsReactive oxygen species Male infertility Lipid peroxidation Oxidative DNA damage DNA repair
J.R.D. drafted the article, which was then edited and revised by R.J.A. Both authors approved the final version of this article.
Conflict of Interest
J.R.D. and R.J.A. are scientific advisors of a US-based biotech company (Celloxess LLC, New Jersey, USA) which has a commercial interest in the detection and treatment of oxidative stress.
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