Pre-Clinical Models of Pain

  • Angela R. Starkweather
  • Cynthia L. Renn
  • Susan G. DorseyEmail author


Animal models of pain serve as a way to study the mechanisms in vivo and from the cell to systems level. Distinct pathologies can be mimicked to represent the pathophysiologic context of pain and interrogate the underlying mechanisms through both cellular and behavioral measures. This chapter will describe the various animal models used to study different types of pain, the challenges in translating animal models to humans, and advances that have been facilitated through animal research.


Animal model Behavioral testing Pain phenotyping 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Angela R. Starkweather
    • 1
  • Cynthia L. Renn
    • 2
  • Susan G. Dorsey
    • 2
    Email author
  1. 1.University of Connecticut School of NursingStorrsUSA
  2. 2.Department of Pain and Translational Symptom ScienceUniversity of Maryland School of NursingBaltimoreUSA

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