Pain Physiology and the Neurobiology of Nociception

  • Cynthia L. RennEmail author
  • Susan G. Dorsey
  • Mari A. Griffioen


Millions of Americans suffer from both acute and chronic pain conditions. While our understanding of the physiological mechanisms underlying pain has increased, pain remains a major healthcare problem in the USA that costs more than $100 million annually for management and due to lost work productivity. The magnitude of the pain problem necessitates that new treatment strategies be discovered, which requires ongoing in-depth research into pain mechanisms, discovery of new therapeutic targets, and the development of new analgesic modalities, both pharmacological and non-pharmacological. This chapter provides a brief overview of pain physiology to help understand where in the pain process new therapeutic targets might be found.


Ascending tracts Modulation Nociception Pain physiology 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Cynthia L. Renn
    • 1
    Email author
  • Susan G. Dorsey
    • 1
  • Mari A. Griffioen
    • 2
  1. 1.Department of Pain and Translational Symptom ScienceUniversity of Maryland School of NursingBaltimoreUSA
  2. 2.University of Delaware School of NursingNewarkUSA

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