Pain Physiology and the Neurobiology of Nociception
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Millions of Americans suffer from both acute and chronic pain conditions. While our understanding of the physiological mechanisms underlying pain has increased, pain remains a major healthcare problem in the USA that costs more than $100 million annually for management and due to lost work productivity. The magnitude of the pain problem necessitates that new treatment strategies be discovered, which requires ongoing in-depth research into pain mechanisms, discovery of new therapeutic targets, and the development of new analgesic modalities, both pharmacological and non-pharmacological. This chapter provides a brief overview of pain physiology to help understand where in the pain process new therapeutic targets might be found.
KeywordsAscending tracts Modulation Nociception Pain physiology
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