Advertisement

Modeling: The New Prospects of Studying Biological Systems as Illustrated by the Human Stomach

  • Svetlana I. MazukhinaEmail author
  • Konstantin V. Chudnenko
  • Pavel S. Tereshchenko
  • Svetlana V. Drogobuzhskaya
  • Stanislav V. Ivanov
Conference paper
  • 98 Downloads
Part of the Lecture Notes in Earth System Sciences book series (LNESS)

Abstract

Thermodynamic modeling was undertaken of the interactions between gastric juice and the mineral water sampled from the Marcial water well and spring in the vicinity of the city of Apatity. The study results make it possible to determine the migration forms of elements in the natural water—gastric juice system in a low and high acidity environment and the deposition conditions of the mineral phases that can be transported from the stomach to other organs and tissues. The physicochemical parameters (Eh and pH) of the studied gastric juice model were examined under normal conditions as well as deficient and excessive HCl. Important factors affecting the change in the gastric juice parameters are temperature and the intake of different mineral water varieties containing different concentrations of the individual elements. It was shown that, in stomach disorders, the transition of iron from the solution to the solid phase occurs, which may explain the anemic condition. A successful treatment of this condition requires restoring the acid-base parameters of the system. The study results complement the existing knowledge and open up new prospects of applying thermodynamic modeling methods to biological systems. An attempt was made to apply the thermodynamic modeling method to study the processes occurring in the human stomach.

Keywords

Stomach model Metabolism Thermodynamic modeling Mineral metabolism Hyperacidity Hypoacidity Migration forms Newly formed phases 

Notes

Acknowledgements

The study was carried out with the financial support of RFBR and the Ministry of Education and Science of Murmansk Region as part of the research project 17-45-510640 p_a “Geochemical examination of the groundwater in the Khibiny Mountains (dating, identification of the origin, chemical composition, migration forms of the elements)”.

References

  1. Agadzhanyan N et al (2006) Human ecology in a changing world. UB RAS, Ekaterinburg (in Russian)Google Scholar
  2. Blanco A, Blanco G (2017a) Medical biochemistry. Academic PressGoogle Scholar
  3. Blanco G, Blanco A (2017b) Medical biochemistry. chapter 12: digestion absorption. Academic PressGoogle Scholar
  4. Bochkov N et al (1999) Directory of general practitioner. In: Paleev NR (ed) EKSMO-Press, in 2 tomes. tome 2 (in Russian)Google Scholar
  5. Borodulin V, Topolyansky A (2007) Directory of practitioners. In: Vorobiev AI (ed) Book 2 (in Russian)Google Scholar
  6. Borodulina GS, Mazukhina SI (2008) Physical-chemical modeling of chalybeate mineral waters composition. In: Ecological problems of the Northern Regions and ways to their solution: proceeding of the Russian scientific conference with international participation, Apatity. KSC RAS. Issue 1, pp 184–188 (in Russian)Google Scholar
  7. Chudnenko K (2010) Thermodynamic modeling in geochemistry: theory, algorithms, software, applications. Akadem publishing house “Geo”, Novosibirsk (in Russian)Google Scholar
  8. Deinega B et al (2014) Physiotherapy and rehabilitation in the practice of a family doctor. Tutorial, Zaporizhzhia (in Ukrainian)Google Scholar
  9. Driscoll CT (1985) Aluminum in acidic surface waters: chemistry, transport and effects. Environ Health Perspect 63:93–104CrossRefGoogle Scholar
  10. Feher J (2012) The stomach. Quantitative human physiology an introductionGoogle Scholar
  11. Gasche C (2013) Iron physiology and pathophysiology in humans. Gastroenterology 144(2):464–465.  https://doi.org/10.1053/j.gastro.2012.12.019CrossRefGoogle Scholar
  12. Izatulina AR et al (2018) Bacterial mechanisms of pathogenic crystallization in the human body. In: VI international symposium on biogenic—abiogenic interactions in natural and anthropogenic systems. VVM publishing Lld, Saint Petersburg, p 21Google Scholar
  13. Kalinnikov V et al (2014) Physical-chemical factors of defect of chemical composition of the Khibiny massif natural waters. DAN 458(5):551–554 (in Russian)CrossRefGoogle Scholar
  14. Kalinnikov V et al (2013) Features of “oil-water” interaction in sea and fresh waters. DAN 449(5):535–538 (in Russian)CrossRefGoogle Scholar
  15. Kolman Ya, Rem К (2000) Visual biochemistry: trans from germ Mir (in Russian)Google Scholar
  16. Kravchenko SM (1998) Calcium-phosphorus ratios in geochemical landscapes and its impact on human health. Geoecology (1):30–36 (in Russian)Google Scholar
  17. Linnik PN, Zhezherya V (2013) Aluminum in the surface waters of Ukraine: content, migration forms, features of distribution among abiotic components. Water Resour 40(2):165–178 (in Russian)CrossRefGoogle Scholar
  18. Mazukhina S et al (2012) Monitoring and physical-chemical modeling of conditions of natural surface and underground waters forming in the Kola North. J Environ Sci Health, Part A: Toxic. Hazard Subst Environ Eng, Part A 47, 657–668 http://doi.org/10.1080/10934529.2012.660037CrossRefGoogle Scholar
  19. Mazukhina SI (2012) Formation of surface and underground waters of the Khibiny mountain massif. In: Masloboev VA (ed) Pupl. Kola Science Centre RAS, Apatity, p 173 (in Russian)Google Scholar
  20. Mazukhina SI et al (2018) Results of the study of groundwater chemical composition in the Khibiny massif and its surroundings (Kola region of the Baltic shield). In: Proceedings of the third Russian scientific conference with international participation “Geological evolution of water-rock interaction”. Chita, pp 122–126.  https://doi.org/10.31554/978-5-7925-0536-0-2018-122-126 (in Russian)
  21. Moiseenko T et al (2010) Impact of industrial waters on the population health of the industrial region of the North. Water Resour 37(2):199–208 (in Russian)CrossRefGoogle Scholar
  22. Prives M et al (2017) Human anatomy. 12th revised and enlarged. Hippocrates (in Russian)Google Scholar
  23. Roitberg G, Strutynsky A (2007) Internal diseases. Digestive system. Study guide. MEDpress-inform, (in Russian)Google Scholar
  24. Rosseeva E et al (2009) Formation of mineral phases in prototypes of human oral fluids. Vestnik of Saint-Petersburg University Series. 7. 2009. Issue 2, pp 12–20 (in Russian)Google Scholar
  25. Rosseeva E et al (2006) Formation of analogues of kidney stones minerals from the prototype of biological fluid under experiment conditions. Mineral Technogenesis 212–233 (in Russian)Google Scholar
  26. Russian statistical yearbook 2017: Rosstat, P76 M., 2017 (in Russian)Google Scholar
  27. Ryzhenko BN et al (2003) Physical-chemical factors of formation of natural waters composition (verification of the model “rock-water”). Geochemistry (6):630–640 (in Russian)Google Scholar
  28. Sapin M, Bilich G (2008) Human anatomy: textbook in 3 т. GEOTAR-Media. Tome 2 (in Russian)Google Scholar
  29. Schmidt W, Bojko J (1999) Regulation of gastric acid secretion. In: Greeley GH (eds) Gastrointestinal endocrinology. Contemporary endocrinology, vol 8. Humana Press, Totowa, NJ.  https://doi.org/10.1007/978-1-59259-695-9_15CrossRefGoogle Scholar
  30. Skalny A (2004) Chemical elements in human physiology and ecology. Mir. Moscow (in Russian)Google Scholar
  31. Skalny A, Rudakov I (2004) Bioelements in medicine. Oniks 21 vek, Mir (in Russian)Google Scholar
  32. Tereshchenko PS et al (2017) Ways of mineral metabolism in the human body and methods of its research. In: Proceedings of Fersman science sessions GI KSC RAS. Issue 14, pp 486–489 (in Russian)Google Scholar
  33. Tutelyan V et al (2001) Vitamins and trace elements in clinical pharmacology. Paleya-M (in Russian)Google Scholar
  34. Vignal C et al (2016) Gut: An underestimated target organ for Aluminum Le tube digestif: unorganecible sous-estimé pour l’aluminium. Morphologie 100(329):75–84.  https://doi.org/10.1016/j.morpho.2016.01.003CrossRefGoogle Scholar
  35. Yokel RA (2016) Reference module in food science. Encyclopedia of food and health, pp 122–127CrossRefGoogle Scholar

Internet Reference

  1. Ministry of Natural Resources and Ecology of the Murmansk region http://mpr.gov-murman.ru (in Russian)

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Svetlana I. Mazukhina
    • 1
    Email author
  • Konstantin V. Chudnenko
    • 2
  • Pavel S. Tereshchenko
    • 3
  • Svetlana V. Drogobuzhskaya
    • 4
  • Stanislav V. Ivanov
    • 5
  1. 1.Institute of North Industrial Ecology Problems—Subdivision of the Federal Research Centre “Kola Science Centre of the Russian Academy of Sciences”Akademgorodok, ApatityRussia
  2. 2.Russia Federal State Budgetary Institution of Science A.P. Vinogradov Institute of Geochemistry SB RASIrkutskRussia
  3. 3.Research Centre for Human Adaptation, Arctic—Branch of the Federal Research Centre, “Kola Science Centre of the Russian Academy of Science”Akademgorodok, ApatityRussia
  4. 4.Tananaev Institute of Chemistry—Subdivision of the Federal Research Centre, “Kola Science Centre of the Russian Academy of Sciences”Akademgorodok, ApatityRussia
  5. 5.Luzin Institute for Economic Studies—Subdivision of the Federal Research Centre, “Kola Science Centre of the Russian Academy of Sciences”ApatityRussia

Personalised recommendations