Brothers with Recurrent Sinopulmonary Infections and Chronic Lung Disease

  • Anastasiia Bondarenko
  • Liudmyla Chernyshova


Late diagnosis in patients with X-linked agammaglobulinemia (XLA) is associated with irreversible pulmonary complications such as bronchiectasis
  • Simple screening methods, such as serum protein fractions may be useful in suspecting of antibody deficiency

  • Medical treatment for XLA is by lifelong immunoglobulin replacement using Intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (SCIG)

  • Use of plasma for immunoglobulin substitution is dangerous due to possibility of transmission of blood-borne infections

  • It is necessary to remember the inexpediency of serological tests is suspicion of infections and using only direct methods of detecting the pathogen


Chronic lung disease Intravenous immunoglobulin Lymphocyte subsets enumeration 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Anastasiia Bondarenko
    • 1
  • Liudmyla Chernyshova
    • 1
  1. 1.Shupyk National Medical Academy for Postgraduate Education, Department of Pediatric Infectious Diseases and Pediatric ImmunologyKievUkraine

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