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Constrictive Aspergillosis Pericarditis

  • Neslihan Edeer Karaca
  • Guzide Aksu
  • Necil Kutukculer
Chapter

Abstract

Staphylococcus aureus, Burkholderia cepacia, Serratia marcescens, Nocardia spp., and Aspergillus spp. are the most common organisms which cause infections in chronic granulomatous disease (CGD) patients

Pneumonia, abscesses, adenitis, and osteomyelitis are the most frequent types of infections

X-linked form of CGD caused by CYBB/gp91phox mutations is more prevalent in western countries affecting two-thirds of CGD patients, while autosomal recessive forms are more prevalent in countries with high rates of consanguineous marriage

Autoinflammatory and/or autoimmune symptoms affecting lungs, gastrointestinal tract, and urogenital system are common in CGD. These symptoms can be the only presentation of CGD in some cases

Liver abscesses or liver granulomas are highly suggestive for CGD even in the absence of other infectious complications.

Invasive fungal infection (IFI) is a major problem in nearly half of the CGD patients. Molds account for more than 60% of IFI with Aspergillus species especially A. Fumigatus and A. nidulans causing 65% of mold infections.

Aspergillus pericarditis is not a frequent pathology in CGD, but must be kept in mind

Keywords

Staphylococcus aureus Burkholderia cepacia Serratia marcescens Nocardia Chronic granulomatous disease Pericarditis 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Neslihan Edeer Karaca
    • 1
  • Guzide Aksu
    • 1
  • Necil Kutukculer
    • 1
  1. 1.Ege University Faculty of Medicine, Department of Pediatric ImmunologyBornovaTurkey

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