Recurrent Pneumonitis

  • Stefano Amoroso
  • Ester Conversano
  • Alberto Tommasini


The diagnosis of leucocyte adhesion deficiency (LAD) type 1 should be considered in children with recurrent infection and persistent neutrophilic leukocytosis even outside infectious episodes

Evaluation of expression of leukocyte adhesion molecules by flow cytometry must be performed to confirm the diagnosis of LAD type 1

Mild-to-moderate disease usually responds to antibiotic therapy, while severe disease requires bone marrow or hematopoietic cell transplantation


Leucocyte adhesion deficiency ITGB2 CD18 Antibiotics 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Stefano Amoroso
    • 1
  • Ester Conversano
    • 1
  • Alberto Tommasini
    • 2
  1. 1.University of TriesteTriesteItaly
  2. 2.Institute for Maternal and Child Health IRCCS “Burlo Garofolo”TriesteItaly

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