Neonatal Jaundice and Leukopenia

  • Mojgan Kianiamin
  • Nima Rezaei


A positive family history of lost sibling due to infections at early age and consanguinity could suggest autosomal recessive immunodeficiencies

BCG vaccination should be avoided in cases with severe combined immunodeficiencies.


BCGitis Hematopoietic stem cell transplantation Adenosine deaminase deficiency Severe combined immunodeficiency 


  1. 1.
    Flinn AM, Gennery AR. Adenosine deaminase deficiency: a review. Orphanet J Rare Dis. 2018;13(1):65.CrossRefGoogle Scholar
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    Kohn DB, Hershfield MS, Puck JM, Aiuti A, Blincoe A, Gaspar HB, Notarangelo LD, Grunebaum E. Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency. J Allergy Clin Immunol. 2019;143(3):852–63.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Mojgan Kianiamin
    • 1
  • Nima Rezaei
    • 2
    • 3
  1. 1.Chamran Medical HospitalTehranIran
  2. 2.Department of Immunology, School of Medicine, Research Center for Immunodeficiencies (RCID), Children’s Medical CenterTehran University of Medical Sciences (TUMS)TehranIran
  3. 3.Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA)Universal Scientific Education and Research Network (USERN)TehranIran

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