Recurrent Otitis and Upper Airway Obstruction

  • Narges Eslami
  • Mehrnaz Mesdaghi
  • Zahra Chavoshzadeh


  • Metabolic checkpoint kinase mTOR, is activated by PI3K, and has a prominent role in promoting dynamic changes in T cell metabolism

  • Gain-of-function mutation in PI3K gene leads to increased mTOR function, which in turn can cause lymphoproliferation


Phosphatidylinositol kinase mTOR Lymphocyte transformation test Lymphoproliferation 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Narges Eslami
    • 1
  • Mehrnaz Mesdaghi
    • 1
  • Zahra Chavoshzadeh
    • 1
  1. 1.Department of Allergy and Clinical ImmunologyMofid Children’s Hospital, Shahid Beheshti University of Medical SciencesTehranIran

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