Recurrent Pneumonia and Fracture in the Femur

  • Selma Scheffler-Mendoza
  • Juan Carlos Bustamante-Ogando
  • Marco Yamazaki-Nakashimada


Autosomal dominant hyper IgE syndrome (AD-HIES) should be included in the differential diagnosis of severe eczema, elevated IgE, and recurrent infections in pediatric patients

AD-HIES is caused by STAT3 mutations, causing immunological and non-immunological clinical manifestation and is considered a multi-systemic disease

Primary objectives for treatment of AD-HIES should entail prevention of both infectious and non-infectious complications

A high index of clinical suspicion among primary care physicians and specialists other than immunologists is essential for AD-HIES diagnosis


Hyper IgE syndrome Eczema STAT3 mutations 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Selma Scheffler-Mendoza
    • 1
  • Juan Carlos Bustamante-Ogando
    • 2
  • Marco Yamazaki-Nakashimada
    • 1
  1. 1.Immunology DepartmentNational Institute of PediatricsMexico CityMexico
  2. 2.Primary Immunodeficiencies Research Unit, National Institute of PediatricsMexico CityMexico

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