Recurrent Meningitis

  • Ibtihal Benhsaien
  • Ahmed Aziz Bousfiha
  • Fatima Ailal


Complement deficiencies are present in up to 20% of patients with disseminated Neisseria infections

Anatomical problems are the leading cause for recurrent meningitis

Meningitis occurs in approximately 40% of individuals with late component complement deficiencies showing a 1000–10,000 fold increase compared to general population

There are no specific treatments for complement deficiencies. Infection prevention and appropriate treatment of infections is key in the care of patients with these deficiencies.

Vaccination is highly recommended against influenza, pneumococcal and meningococcal diseases. Immunization against Neisseria meningitides with a tetravalent conjugate vaccine is strongly recommended

Quadrivalent meningococcal polysaccharide–protein conjugate vaccines against meningococcal serogroups A, C, W, and Y appear to be superior to tetravalent vaccines for long-term individual protection


Quadrivalent meningococcal vaccine Complement deficiency C4 deficiency 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ibtihal Benhsaien
    • 1
    • 2
  • Ahmed Aziz Bousfiha
    • 1
    • 2
  • Fatima Ailal
    • 1
    • 2
  1. 1.Clinical Immunology Unit, Harouchi Children Hospital, Ibn Rochd Hospital UniversityCasablancaMorocco
  2. 2.Clinical Immunology, Autoimmunity and Autoinflammatory Laboratory (LICIA)CasablancaMorocco

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