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Enterocolitis Followed by Recurrent Sepsis-Like Episodes

  • Tania Siahanidou
  • Sofia Tantou
  • Maria Kanariou
Chapter

Abstract

Autoinflammatory diseases should be included in the differential diagnosis of recurrent episodes of systemic inflammation, as early as in the neonatal age

NLRC4 mutations can cause life threatening macrophage activation syndrome

Early DNA analysis and identification of the responsible gene is crucial for early diagnosis in order to decide the most appropriate therapy and improve patients prognosis

Keywords

NLRC4 Inflammasome IL-1β Whole exome sequencing 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Tania Siahanidou
    • 1
  • Sofia Tantou
    • 2
  • Maria Kanariou
    • 2
  1. 1.First Department of PediatricsNational & Kapodistrian University of Athens, “Aghia Sophia” Children’s HospitalAthensGreece
  2. 2.Department of Immunology-HistocompatibilitySpecialized Center & Referral Center for Primary Immunodeficiencies, Pediatric Immunology, “Aghia Sophia” Children’s HospitalAthensGreece

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