Preventing Chemotherapy-Induced Onycholysis with the Use of an Active Local Cooling Device

  • Muriel De BoeckEmail author
  • Jochen Vleugels
  • Marc Peeters
  • Guido De Bruyne
Conference paper
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 957)


Chemotherapy-induced onycholysis is a severe form of nail toxicity, characterized by partial or complete detachment of the nail from the nail bed. This medical condition is caused by the presence of taxanes in the patient’s blood while undergoing chemotherapy and is observed in 0 to 44% of cancer patients. The taxanes limit rapid cell reproduction, treating cancer, but also bring deterioration to the nail and nail bed structure. Cryotherapy is currently used in the form of passive cooling for the prevention of onycholysis. Ice gloves are cryotherapeutic applications that are used during chemotherapy to prevent nail toxicity. Although they are significantly effective, they cause extreme cold and pain. In this research, the effectiveness of a five-finger active cooling device was examined to control the blood flow at the distal phalanges at one hand, while increasing the patient’s comfort.


Chemotherapy Nail toxicity Onycholysis Cryotherapy Cold-Induced Vasodilation 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Muriel De Boeck
    • 1
    Email author
  • Jochen Vleugels
    • 1
  • Marc Peeters
    • 1
  • Guido De Bruyne
    • 1
  1. 1.Department Product DevelopmentUniversity of AntwerpAntwerpBelgium

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