Advertisement

Preventing Chemotherapy-Induced Onycholysis with the Use of an Active Local Cooling Device

  • Muriel De BoeckEmail author
  • Jochen Vleugels
  • Marc Peeters
  • Guido De Bruyne
Conference paper
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 957)

Abstract

Chemotherapy-induced onycholysis is a severe form of nail toxicity, characterized by partial or complete detachment of the nail from the nail bed. This medical condition is caused by the presence of taxanes in the patient’s blood while undergoing chemotherapy and is observed in 0 to 44% of cancer patients. The taxanes limit rapid cell reproduction, treating cancer, but also bring deterioration to the nail and nail bed structure. Cryotherapy is currently used in the form of passive cooling for the prevention of onycholysis. Ice gloves are cryotherapeutic applications that are used during chemotherapy to prevent nail toxicity. Although they are significantly effective, they cause extreme cold and pain. In this research, the effectiveness of a five-finger active cooling device was examined to control the blood flow at the distal phalanges at one hand, while increasing the patient’s comfort.

Keywords

Chemotherapy Nail toxicity Onycholysis Cryotherapy Cold-Induced Vasodilation 

References

  1. 1.
    Verweij, J., Clavel, M., Chevalier, B.: Paclitaxel (Taxol) and docetaxel (Taxotere): not simply two of a kind. Ann. Oncol. 5(6), 495–505 (1994)CrossRefGoogle Scholar
  2. 2.
    Robert, C., et al.: Nail toxicities induced by systemic anticancer treatments. Lancet Oncol. 16(4), e181–e189 (2015)CrossRefGoogle Scholar
  3. 3.
    Gilbar, P., Hain, A., Peereboom Veta-Marie, V.M.: Nail toxicity induced by cancer chemotherapy. J. Oncol. Pharm. Pract. 15(3), 143–155 (2009)CrossRefGoogle Scholar
  4. 4.
    Minisini, A.M., et al.: Taxane-induced nail changes: incidence, clinical presentation and outcome. Ann. Oncol. 14(2), 333–337 (2003)CrossRefGoogle Scholar
  5. 5.
    Bladt, L., et al.: Cold-induced vasoconstriction for preventing onycholysis during cancer treatment. Extrem. Physiol. Med. 4(1), A60 (2015)CrossRefGoogle Scholar
  6. 6.
    Hussain, S., Anderson, D.N., Salvatti, M.E., Adamson, B., McManus, M., Braverman, A.S.: Onycholysis as a complication of systemic chemotherapy: report of five cases associated with prolonged weekly paclitaxel therapy and review of the literature. Cancer 88(10), 2367–2371 (2000)CrossRefGoogle Scholar
  7. 7.
    Scotté, F., et al.: Matched case-control phase 2 study to evaluate the use of a frozen sock to prevent docetaxel-induced onycholysis and cutaneous toxicity of the foot. Cancer 112(7), 1625–1631 (2008)CrossRefGoogle Scholar
  8. 8.
    Cancer Therapy Evaluation Program: Common terminology criteria for adverse events Version 3.0. Publish, p. 71 (2006)Google Scholar
  9. 9.
    Jadhav, V.M., Mahajan, P.M., Mhaske, C.B.: Nail pitting and onycholysis. Indian J. Dermatol. Venereol. Leprol. 75(6), 631–634 (2009)CrossRefGoogle Scholar
  10. 10.
    Kadakia, K.C., Rozell, S.A., Butala, A.A., Loprinzi, C.L.: Supportive cryotherapy: a review from head to toe. J. Pain Symptom Manage. 47(6), 1100–1115 (2014)CrossRefGoogle Scholar
  11. 11.
    Tyler, C.J., Reeve, T., Cheung, S.S.: Cold-induced vasodilation during single digit immersion in 0 °C and 8 °C water in men and women. PLoS ONE 10(4), 1–13 (2015)CrossRefGoogle Scholar
  12. 12.
    Daanen, H.A.M.: Finger cold-induced vasodilation: a review. Eur. J. Appl. Physiol. 89(5), 411–426 (2003)CrossRefGoogle Scholar
  13. 13.
    Lemenager, M., Lecomte, S., Bonneterre, M.E., Bessa, E., Dauba, J., Bonneterre, J.: Effectiveness of cold cap in the prevention of docetaxel-induced alopecia. Eur. J. Cancer Part A 33(2), 297–300 (1997)CrossRefGoogle Scholar
  14. 14.
    Scotté, F., et al.: Multicenter study of a frozen glove to prevent docetaxel-induced onycholysis and cutaneous toxicity of the hand. J. Clin. Oncol. 23(19), 4424–4429 (2005)CrossRefGoogle Scholar
  15. 15.
    Ishiguro, H., et al.: Degree of freezing does not affect efficacy of frozen gloves for prevention of docetaxel-induced nail toxicity in breast cancer patients. Support. Care Cancer 20(9), 2017–2024 (2012)CrossRefGoogle Scholar
  16. 16.
    Steckel, J., et al.: A research platform using active local cooling directed at minimizing the blood flow in human fingers. In: Proceeding of ICTs Improving Patients Rehabilitation Research Techniques, pp. 81–84 (2013)Google Scholar
  17. 17.
    Youssef, A., D’Haene, M., Vleugels, J., De Bruyne, G., Aerts, J.-M.: Localised model-based active controlling of blood flow during chemotherapy to prevent nail toxicity and onycholysis. J. Med. Biol. Eng. 39, 1–12 (2018). No. 0123456789Google Scholar
  18. 18.
    De Boeck, M., et al.: Prevention of onycholysis during cancer treatment using an active local cooling device: comparison of three different cooling strategies. Adv. Intell. Syst. Comput. 818, 214–221 (2019)Google Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Muriel De Boeck
    • 1
    Email author
  • Jochen Vleugels
    • 1
  • Marc Peeters
    • 1
  • Guido De Bruyne
    • 1
  1. 1.Department Product DevelopmentUniversity of AntwerpAntwerpBelgium

Personalised recommendations