Cell-Based Cardiovascular Regenerative Therapies

  • Ray P. Prajnamitra
  • Yuan-Yuan Cheng
  • Li-Lun Chen
  • Patrick C. H. HsiehEmail author


Cardiovascular diseases remain a leading cause of death worldwide with ischemic heart disease being the most common cause. Due to the poor proliferation capability of adult cardiomyocytes, an injured heart is incapable of replacing its lost myocardium. Instead, the heart heals through formation of fibrotic scar tissue which, unlike cardiomyocytes, lacks contractile capability. This gradually weakens the heart and in the long term may result in heart failure. Efforts to aid the heart in regenerating its lost cardiomyocytes have been concentrated on using stem cells as a source of new cells. In this chapter, we focus on the recent developments, challenges, and improvements that researchers around the world have made in the field of cell-based regenerative therapy, such as pluripotent stem cell- and adult stem cell-derived cardiomyocytes. Although there are still problems that need to be addressed, studies up to date have shown promising results in recovering the lost cardiomyocytes and ultimately improving heart function after injury.


Pluripotent stem cells iPSC ESC Cardiomyocytes Cell reprogramming Cardiovascular disease 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ray P. Prajnamitra
    • 1
  • Yuan-Yuan Cheng
    • 1
  • Li-Lun Chen
    • 1
  • Patrick C. H. Hsieh
    • 1
    Email author
  1. 1.Institute of Biomedical Sciences, Academia SinicaTaipeiTaiwan

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