Alternative Mechanisms of mRNA Translation Initiation in Cellular Stress Response and Cancer

  • Rafaela Lacerda
  • Juliane Menezes
  • Marco M. Candeias
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1157)


Throughout evolution, eukaryotic cells have devised different mechanisms to cope with stressful environments. When eukaryotic cells are exposed to stress stimuli, they activate adaptive pathways that allow them to restore cellular homeostasis. Most types of stress stimuli have been reported to induce a decrease in overall protein synthesis accompanied by induction of alternative mechanisms of mRNA translation initiation. Here, we present well-studied and recent examples of such stress responses and the alternative translation initiation mechanisms they induce, and discuss the consequences of such regulation for cell homeostasis and oncogenic transformation.


mRNA translation Alternative translation initiation Cellular stress Cancer IRES Non-AUG 



Marco M Candeias was partially supported by grants PTDC/MED-ONC/32048/2017 and PTDC/BIMONC/4890/2014 from Fundação para a Ciência e a Tecnologia (FCT), by Grants-in-Aid 16K21111 and 18K07229 from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan, by Takeda Foundation and Astellas Foundation. Juliane Menezes is a posdoc fellow (SFRH/BPD/98360/2013) from FCT.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Rafaela Lacerda
    • 1
    • 2
  • Juliane Menezes
    • 1
    • 2
  • Marco M. Candeias
    • 1
    • 3
  1. 1.Department of Human GeneticsNational Institute of Health Doutor Ricardo JorgeLisboaPortugal
  2. 2.Faculty of Sciences, BioISI – Biosystems & Integrative Sciences InstituteUniversity of LisbonLisboaPortugal
  3. 3.MaRCU – Molecular and RNA Cancer Unit, Graduate School of MedicineKyoto UniversityKyotoJapan

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