Advertisement

The Interplay Between Living Donor Liver Transplantation and Liver Surgery

  • Andrea LauterioEmail author
  • Riccardo De Carlis
  • Stefano Di Sandro
  • Luciano De Carlis
Chapter
Part of the Updates in Surgery book series (UPDATESSURG)

Abstract

The evolution of living donor liver transplantation (LDLT) has spurred advances in complex liver surgery. Refinements in living donor liver surgery along with a better understanding of the liver anatomy and live donor liver volumetry have been applied to resective hepatic surgery, improving outcomes after major liver resection. Likewise, advances in resective hepatic surgery has led to both the split-liver technique and LDLT. The overall result has been the development of innovative techniques, such as two-stage hepatectomy, and the association of liver partition and portal vein ligation, combining aspects of liver resection surgery and partial graft transplantation.

This chapter reviews the surgical and clinical advances in liver surgery and LDLT, focusing on developments worldwide and in Italy, donor and recipient outcomes, and prospects for the further expansion and application of these complex surgical procedures.

Keywords

Liver transplantation Living donor liver transplantation LDLT Split liver Liver surgery Small-for-size syndrome 

Supplementary material

Video 8.1

(MOV 210250 kb)

References

  1. 1.
    Couinaud C. Le foie. Etudes anatomiques et chirurgicales. Paris: Masson Editeur; 1957.Google Scholar
  2. 2.
    Tùng TT. Les résections majeures et mineures du foie. Paris: Masson Editeur; 1979.Google Scholar
  3. 3.
    Bismuth H, Houssin D. Reduced-sized orthotopic liver graft in hepatic transplantation in children. Surgery. 1984;95:367–70.PubMedGoogle Scholar
  4. 4.
    Broelsch CE, Emond JC, Thistlethwaite JR, et al. Liver transplantation with reduced size donor organs. Transplantation. 1988;45:519–23.CrossRefGoogle Scholar
  5. 5.
    Broelsch CE, Emond JC, Thistlethwaite JR, et al. Liver transplantation, including the concept of reduced size liver transplants in children. Ann Surg. 1988;208:410–20.CrossRefGoogle Scholar
  6. 6.
    Pichlmayr R, Ringe B, Gubernatis G, et al. Transplantation of a donor liver to 2 recipients (splitting transplantation) – a new method in the further development of segmental liver transplantation. Langenbecks Arch Chir. 1988;373:127–30.CrossRefGoogle Scholar
  7. 7.
    Strong RW, Lynch SV, Hong TH. Successful liver transplantation from a living donor to her son. N Engl J Med. 1990;322:1505–7.CrossRefGoogle Scholar
  8. 8.
    Hashikura Y, Makuuchi M, Kawasaki S, et al. Successful living-related partial liver transplantation to an adult patient. Lancet. 1994;343:1233–4.CrossRefGoogle Scholar
  9. 9.
    Yamaoka Y, Washida M, Honda K, et al. Liver transplantation using a right lobe graft from a living related donor. Transplantation. 1994;57:1127–30.CrossRefGoogle Scholar
  10. 10.
    Miller CM, Durand F, Heimbach JK, et al. The International Liver Transplant Society Guideline on living liver donation. Transplantation. 2016;100:1238–43.CrossRefGoogle Scholar
  11. 11.
    Sugawara Y, Makuuchi M, Takayama T, et al. Small-for-size grafts in living-related liver transplantation. J Am Coll Surg. 2001;192:510–3.CrossRefGoogle Scholar
  12. 12.
    Dahm F, Georgiev P, Clavien PA. Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications. Am J Transplant. 2005;5:2605–10.CrossRefGoogle Scholar
  13. 13.
    Ben-Haim M, Emre S, Fishbein TM, et al. Critical graft size in adult-to-adult living donor liver transplantation: impact of the recipient’s disease. Liver Transpl. 2001;7:948–53.CrossRefGoogle Scholar
  14. 14.
    Rahbari NN, Garden OJ, Padbury R, et al. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery. 2011;149:713–24.CrossRefGoogle Scholar
  15. 15.
    Troisi RI, Berardi G, Tomassini F, Sainz-Barriga M. Graft inflow modulation in adult-to-adult living donor liver transplantation: a systematic review. Transplant Rev. 2017;31:127–35.CrossRefGoogle Scholar
  16. 16.
    Schnitzbauer AA, Lang SA, Goessmann H, et al. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg. 2012;255:405–14.CrossRefGoogle Scholar
  17. 17.
    Wakabayashi G, Cherqui D, Geller DA, et al. Recommendations for laparoscopic liver resection: a report from the second international consensus conference held in Morioka. Ann Surg. 2015;261:619–29.Google Scholar
  18. 18.
    Ratner LE, Hiller J, Sroka M, et al. Laparoscopic live donor nephrectomy removes disincentives to live donation. Transplant Proc. 1997;29:3402–3.CrossRefGoogle Scholar
  19. 19.
    Soubrane O, Cherqui D, Scatton O, et al. Laparoscopic left lateral sectionectomy in living donors: safety and reproducibility of the technique in a single center. Ann Surg. 2006;244:815–20.CrossRefGoogle Scholar
  20. 20.
    Soubrane O, de Rougemont O, Kim K-H, et al. Laparoscopic living donor left lateral sectionectomy: a new standard practice for donor hepatectomy. Ann Surg. 2015;262:757–61.CrossRefGoogle Scholar
  21. 21.
    Samstein B, Cherqui D, Rotellar F, et al. Totally laparoscopic full left hepatectomy for living donor liver transplantation in adolescents and adults. Am J Transplant. 2013;13:2462–6.CrossRefGoogle Scholar
  22. 22.
    Rotellar F, Pardo F, Benito A, et al. Totally laparoscopic right-lobe hepatectomy for adult living donor liver transplantation: useful strategies to enhance safety. Am J Transplant. 2013;13:3269–73.CrossRefGoogle Scholar
  23. 23.
    Giulianotti PC, Tzvetanov I, Jeon H, et al. Robot-assisted right lobe donor hepatectomy. Transpl Int. 2012;25:e5–9.CrossRefGoogle Scholar
  24. 24.
    Lee SG. A complete treatment of adult living donor liver transplantation: a review of surgical technique and current challenges to expand indication of patients. Am J Transplant. 2015;15:17–38.CrossRefGoogle Scholar
  25. 25.
    Centro Nazionale Trapianti. Attività di donazione e trapianto di organi in Italia – Report 2017. http://www.trapianti.salute.gov.it/imgs/C_17_cntPubblicazioni_224_allegato.pdf. Accessed 24 Feb 2019.
  26. 26.
    Nadalin S, Capobianco I, Panaro F, et al. Living donor liver transplantation in Europe. Hepatobiliary Surg Nutr. 2016;5:159–75.PubMedPubMedCentralGoogle Scholar
  27. 27.
    Lauterio A, Di Sandro S, Gruttadauria S, et al. Donor safety in living donor liver donation: an Italian multicenter survey. Liver Transpl. 2017;23:184–93.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Andrea Lauterio
    • 1
    Email author
  • Riccardo De Carlis
    • 1
    • 2
  • Stefano Di Sandro
    • 1
  • Luciano De Carlis
    • 1
    • 3
  1. 1.Department of General Surgery and TransplantationNiguarda HospitalMilanItaly
  2. 2.Department of Surgical SciencesUniversity of PaviaPaviaItaly
  3. 3.School of Medicine and SurgeryUniversity of Milano-BicoccaMilanItaly

Personalised recommendations