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Beta Blockers and Calcium Channel Blockers

  • Alexandra-Maria Neagoe
  • Emrush Rexhaj
  • Ehud Grossman
  • Franz H. Messerli
Chapter
Part of the Contemporary Cardiology book series (CONCARD)

Abstract

Calcium channel blockers and beta blockers are medicines commonly prescribed for the treatment of hypertension and tachyarrhythmias. Beta blockers prevent stimulation of the beta-adrenergic receptors at the nerve endings of the sympathetic nervous system and therefore reduce systolic pressure, heart rate, and cardiac contractility and output. Calcium channel blockers block voltage-gated calcium channels and inhibit the influx of calcium ions into cardiac and smooth muscle cells. The decrease in intracellular calcium inhibits cardiac contraction, but promotes vasodilatation. Beta blockers are likely overprescribed; they are ineffective antihypertensive agents. Current evidence supports their use in patients with systolic heart failure and for rate control.

Keywords

Beta blocker Calcium channel blocker Heart failure Hypertension Arrhythmia Hemodynamics 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Alexandra-Maria Neagoe
    • 1
  • Emrush Rexhaj
    • 1
    • 2
  • Ehud Grossman
    • 3
  • Franz H. Messerli
    • 4
  1. 1.Department of CardiologyUniversity Hospital BernBernSwitzerland
  2. 2.Department for Biomedical ResearchUniversity of BernBernSwitzerland
  3. 3.The Chaim Sheba Medical Center, The Sackler Faculty of MedicineTel-Aviv UniversityTel AvivIsrael
  4. 4.Department of CardiologyUniversity of BernBernSwitzerland

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